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Breast Cancer Blog: Promising Results With Advexin In Breast Cancer

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Dec 13, 2005

Promising Results With Advexin In Breast Cancer

Promising Results With Advexin In Breast Cancer
Advexin uses the p53 tumor suppressor gene to kill cancer cells or stops tumor growth via an adenoviral delivery system that does not harm normal cells. Patients are given large quantities of the nontoxic p53 gene, which then overtake cancer cells and are cleared quickly from the body.

Introgen Therapeutics updated its phase 2 trial evaluating Advexin combined with neoadjuvant (pre-operative) chemotherapy and surgery in women with locally advanced breast cancer. After 35 months of follow-up, 92 per cent of the treated patients are alive and 83 per cent have survived without evidence of disease recurrence.

All the patients participated in the study showed an average 80 per cent reduction in tumor size. Following tumor shrinkage, complete tumor removal by subsequent surgery was achieved in 100 per cent of the patients. The results of the therapy with the addition of Advexin are better than what would be expected from neoadjuvant chemotherapy treatment alone, claims a company release.

Neoadjuvant treatments are administered prior to surgery and represent a novel and increasingly applied approach to make surgical tumour resections either more complete improving outcomes or less invasive facilitating breast conservation.

The company says the data is very encouraging, and suggest that Advexin may be combined with neoadjuvant chemotherapy to improve patient outcomes by reducing tumor size thereby permitting complete surgical tumor removal. The results of this study indicate that Advexin may enhance the clinical benefit of chemotherapies without increasing their toxicity and support clinical applications of Advexin in earlier phases of cancer treatment.

Company representatives state that prior preclinical and clinical studies indicate that Advexin interacts synergistically with many standard anti-cancer therapies and it is not surprising to find that the combination of Advexin with chemotherapy in these patients is generating encouraging results.

Introgen has received FDA fast track designation for Advexin therapy and Advexin has been designated as an orphan drug for the treatment of head and neck cancer under the Orphan Drug Act.


Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer. publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.


Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women.

Breast Cancer Blog: Promising Results With Advexin In Breast Cancer

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