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Breast Cancer Blog: COX-2 Inhibitors May Cut Breast Cancer Risk

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Feb 16, 2006

COX-2 Inhibitors May Cut Breast Cancer Risk

COX-2 Inhibitors May Cut Breast Cancer Risk
Those who use the popular painkillers belonging to the group of COX-2 inhibitors and other nonsteroidal anti-inflammatory agents (NSAIDs) regularly may derive substantial benefit in terms of breast cancer protection from the therapy, as per the research report published in the journal BMC Cancer. Popular COX-2 inhibitors include Celebrex and Vioxx. Vioxx have been recently removed from the market due to the concerns of increased risk of heart attack associated with this drug.

The Lead researcher, Dr. Randall Harris and colleagues from the Ohio State College of Medicine and Public Health in Columbus studied 323 breast cancer patients and 649 cancer-free controls to come to this conclusion. They observed a 71 percent reduction in the risk of breast cancer with the use of selective COX-2 inhibitors, such as Celebrex and Vioxx, for 2 years or more. Benefits were also observed for those who use ibuprofen and regular full dose (325 mg) of aspirin, but the amount of benefit was less compared to use of COX-2 inhibitors. There were no significant benefits observed with the use of acetaminophen, which has negligible COX-2 activity, or with low-dose (81 mg) aspirin.

Dr. Harris, says that this leads stronger evidence for the theory that COX-2 overexpression may lead to breast cancer and opens up potential avenues for chemoprevention and possibly therapy with selective COX-2 blocking agents.

COX-2 inhibitors have been recently implicated in causing increased risk of heart attacks. COX-2 inhibitors have also been shown to be beneficial in other cancers. Additional clinical studies are required to establish the safety and efficacy of COX-2 inhibitors in the treatment of breast cancer.


Sherin      



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Janet      


Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women.

Breast Cancer Blog: COX-2 Inhibitors May Cut Breast Cancer Risk

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