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Breast Cancer Blog: COX-2 Inhibitors May Cut Breast Cancer Risk

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Feb 16, 2006

COX-2 Inhibitors May Cut Breast Cancer Risk

COX-2 Inhibitors May Cut Breast Cancer Risk
Those who use the popular painkillers belonging to the group of COX-2 inhibitors and other nonsteroidal anti-inflammatory agents (NSAIDs) regularly may derive substantial benefit in terms of breast cancer protection from the therapy, as per the research report published in the journal BMC Cancer. Popular COX-2 inhibitors include Celebrex and Vioxx. Vioxx have been recently removed from the market due to the concerns of increased risk of heart attack associated with this drug.

The Lead researcher, Dr. Randall Harris and colleagues from the Ohio State College of Medicine and Public Health in Columbus studied 323 breast cancer patients and 649 cancer-free controls to come to this conclusion. They observed a 71 percent reduction in the risk of breast cancer with the use of selective COX-2 inhibitors, such as Celebrex and Vioxx, for 2 years or more. Benefits were also observed for those who use ibuprofen and regular full dose (325 mg) of aspirin, but the amount of benefit was less compared to use of COX-2 inhibitors. There were no significant benefits observed with the use of acetaminophen, which has negligible COX-2 activity, or with low-dose (81 mg) aspirin.

Dr. Harris, says that this leads stronger evidence for the theory that COX-2 overexpression may lead to breast cancer and opens up potential avenues for chemoprevention and possibly therapy with selective COX-2 blocking agents.

COX-2 inhibitors have been recently implicated in causing increased risk of heart attacks. COX-2 inhibitors have also been shown to be beneficial in other cancers. Additional clinical studies are required to establish the safety and efficacy of COX-2 inhibitors in the treatment of breast cancer.


Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer. publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.


Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women.

Breast Cancer Blog: COX-2 Inhibitors May Cut Breast Cancer Risk

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