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Breast Cancer Blog: Obesity And Estrogen Related To Breast Cancer

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Feb 27, 2006

Obesity And Estrogen Related To Breast Cancer

Obesity And Estrogen Related To Breast Cancer
Obesity and estrogen breakdown products may play a significant role in the development of breast cancer, among those women who never used hormone therapy, as per findings published in the International Journal of Cancer.

Dr. Francesmary Modugno, of the University of Pittsburgh, and colleagues, studied the effects of obesity and say "Hormone therapy and body mass index (BMI) have been associated with postmenopausal breast cancer...... Because estrogen metabolism may affect breast cancer risk and can be altered by weight and hormone therapy, it might play a role in the hormone therapy-BMI-breast cancer associations."

These researchers reached this conclusion after analyzing data from women enrolled in the Observational Study of the Women's Health Initiative. They compared levels of two estrogen metabolic products, in 200 women who developed breast cancer and in 200 women who did not.

The researchers found that in women who used hormone therapy, there was a modest but significant increase in breakdown products of estrogen. In this group of women, there was no association among BMI, estrogen metabolism and breast cancer risk.

On the other hand in the group of women who did not use hormone therapy greater BMI and higher levels of estrogen breakdown products were individually and jointly associated with increased cancer risk. The study showed that women with high BMI and high estrogen breakdown products had 3.5-times more likely to develop breast cancer compared to their counterparts.

Sherin      



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Janet      


b>Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women

Breast Cancer Blog: Obesity And Estrogen Related To Breast Cancer

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