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Breast Cancer Blog: New Protein Marker To Predict Breast Cancer Outcome

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Jan 11, 2006

New Protein Marker To Predict Breast Cancer Outcome

New Protein Marker To Predict Breast Cancer Outcome
Researchers have found a new protein marker that can predict the outcome in breast cancer. Presence of this new marker protein called, alpha-basic-crystalline in the breast tumor may indicate poor survival in breast cancer as per researchers Vincent Cryns and colleagues at Northwestern University.

It would be good if we can know with certainty how a woman's breast cancer is going to behave in future. Researchers have been trying to find genes and proteins that can predict the outcome of breast cancer, with the main idea of classifying breast cancer into low risk and high-risk groups. At this time we do not have a good method to classify low risk and high-risk breast cancer patients and as result most of the patients receive toxic chemotherapies.

A new predictive test that was introduced recently called Oncotype-Dx testing makes some progress in this regard. This test can predict a woman's risk of breast cancer recurrence in the next 10 years. Test is useful in borderline circumstances when treatment decision about chemotherapy is in question. Newer tests are introduced and when they are available we may be able to predict with accuracy if a woman with breast cancer would require chemotherapy.

Coming back to the point, these researchers have been examining the genes expressed during breast cancer in order to classify those genes into groups that can reliably predict the outcome of disease. These researchers found that a protein that is found in some breast cancer tumors called alpha-basic-crystallin, predicts poor survival in breast cancer. This predictive value of alpha-basic-crystalline was independently of other known prognostic markers.

Alpha-basic-crystallin is overexpressed in mammary epithelial cells and causes dysregulated growth, changes in cell structure, diminished programmed cell death, and the formation of invasive carcinomas that is linked to activation of the ERK/MAPK signaling pathway. Researchers say that these new findings may facilitate research and development of tailored therapies that are active against this signaling pathway.
This study appears in the recent issue of Journal of Clinical Investigation.


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Do you read all of the blogs published by Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer. publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.


Breast cancer
Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women.

Breast Cancer Blog: New Protein Marker To Predict Breast Cancer Outcome

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