Breast Cancer Blog: From Medicineworld.org
Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.
Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.
Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.
Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.
Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.
Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.
Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.
Feb 21, 2006
HRT And Risk Of Tubular Breast Cancers
Postmenopausal hormone replacement therapy (HRT) using estrogen-progestin combinations may be associated with a more than two-fold higher relative risk of developing lobular cancer or tubular cancer than of developing ductal cancer. These results come from a large study from Europe, which was recently published in the journal Breast Cancer Research. Findings from this research show for the first time that estrogen-progestin therapy combination is associated with a higher relative risk of developing tubular cancer than ductal cancer, when taken for more than five years. This study also confirms previous findings that postmenopausal hormone therapy using estrogen-progestin is associated with a higher relative risk of lobular cancer than ductal cancer.
This study was conducted by Lena Rosenberg and colleagues from the Karolinska Institutet in Stockholm, Sweden together with researchers from Genome Institute of Singapore. They combed through the records of 1,888 women with ductal breast cancer, 308 women with lobular cancer and 93 women with tubular breast cancer. All women were matched for age with 3,065 women randomly selected from the population, acted as controls. Both patients and controls were asked to fill in a questionnaire about their medical history, health status and use of menopausal hormone therapy.
Results of the published study show that women who used medium potency estrogen-progestin combination therapy had a higher risk of developing lobular or tubular breast cancer than of developing ductal cancer, compared with women who did not use hormone therapy. Woman who used combination therapy for more than five years were at higher risk for any of these subtypes of breast cancers.
Feb 17, 2006
MRI And Mammography
Researchers have found that mammography coupled with magnetic resonance imaging (MRI) is extremely sensitive in the detection of ductal carcinoma in situ (DCIS). DCIS, or early stage breast carcinoma, is a pre-invasive malignancy and MRI may help identify this type of disease, which may not be visible on a mammogram. This study is published in The Breast Journal.
The study examined the medical records of women diagnosed with DCIS, aged 34 to 79 years, who underwent MRI and mammographic examinations during a period of approximately two years. The results revealed 39 sites of pure DCIS in 33 breasts of 32 women. In each of these women, both MRI and mammograms were performed prior to surgery. Of the 33 breasts involved, DCIS was detected by MRI alone in 64 percent, and detected by mammography alone in only 3 percent. MRI and mammography together detected DCIS in 24 percent of breasts; in 9%, DCIS was found at mastectomy but the mammogram and MRI were negative.
"The results from our small, select group of patients suggest that in women with known or suspected DCIS, determination of the presence and extent of disease may be best established with mammography complemented by MRI," say researchers.
The nuclear grade of DCIS detected by MRI and mammography was similar, though the size of lesions identified by MRI was larger. Breast density did not affect the results.
The American Cancer Society recommends that women age 40 and older should have a mammogram every year and that those at increased risk should talk with their doctors about the benefits and limitations of starting mammograms when they are younger, having additional tests (such as MRI) or having more frequent exams. Source: http://www.blackwellpublishing.com/
Feb 16, 2006
COX-2 Inhibitors May Cut Breast Cancer Risk
Those who use the popular painkillers belonging to the group of COX-2 inhibitors and other nonsteroidal anti-inflammatory agents (NSAIDs) regularly may derive substantial benefit in terms of breast cancer protection from the therapy, as per the research report published in the journal BMC Cancer. Popular COX-2 inhibitors include Celebrex and Vioxx. Vioxx have been recently removed from the market due to the concerns of increased risk of heart attack associated with this drug.
The Lead researcher, Dr. Randall Harris and colleagues from the Ohio State College of Medicine and Public Health in Columbus studied 323 breast cancer patients and 649 cancer-free controls to come to this conclusion. They observed a 71 percent reduction in the risk of breast cancer with the use of selective COX-2 inhibitors, such as Celebrex and Vioxx, for 2 years or more. Benefits were also observed for those who use ibuprofen and regular full dose (325 mg) of aspirin, but the amount of benefit was less compared to use of COX-2 inhibitors. There were no significant benefits observed with the use of acetaminophen, which has negligible COX-2 activity, or with low-dose (81 mg) aspirin.
Dr. Harris, says that this leads stronger evidence for the theory that COX-2 overexpression may lead to breast cancer and opens up potential avenues for chemoprevention and possibly therapy with selective COX-2 blocking agents.
COX-2 inhibitors have been recently implicated in causing increased risk of heart attacks. COX-2 inhibitors have also been shown to be beneficial in other cancers. Additional clinical studies are required to establish the safety and efficacy of COX-2 inhibitors in the treatment of breast cancer.
Feb 15, 2006
Breast Scanner May Replace Mammography
Photo: Martin Tornai, Ph.D., associate professor of radiology and biomedical engineering at Duke University Medical Center with the 3-D breast scanner (photo credit Duke University Medical Center).Researchers at Duke University have created a new type of breast scanner that will dramatically improve their ability to visualize small tumors while also reducing radiation exposure to one-tenth that of normal mammograms. This may also provide relief from the often-painful experience of breast compression that is involved in the traditional mammograms.
These new scanner uses computed tomography (CT), which is the same technique used in obtaining a CT scan of the chest, but with a unique variation: it provides a three-dimensional image of the breast. The new scanner is capable of rotating around the breast to obtain a complete image of the breast, from the nipple to the chest wall. On the other hand, traditional mammograms provide only a two-dimensional image and they compress the breast, thereby distorting the image and causing discomfort for many women.
The Duke researchers have successfully demonstrated their new CT scanner can detect lesions as small as 5 mm in artificial breast models and in cadavers. Current threshold of detection of soft tissue tumors in mammograms are estimated to be around 1 cm, which is about the size of a marble. However mammogram can detect far smaller micro-calcifications, which could be indicators of disease.
The Duke scientists expect that this scanner would be ready for use within two years and is in the process of developing a start-up company to commercialize the device.
Traditional mammography fails to detect some tumors because it is two-dimensional and thus projects a flattened image of the breast. The compression and two-dimensional image cause overlapped tissues to obscure some tumors. With 3-D imaging, the breast is fully depicted and the contrast between normal and cancerous tissues would be more apparent.
Feb 13, 2006
More Likely To Be Diagnosed With Breast Cancer In Summer
[imgl]/images/blog/summer-woman-654580.jpg[/imgl]Scientists have observed that woman generally tend to have diagnosis of breast cancer in spring and summer months compared rest of the year. They believe that this is due to the fact that women are more aware of their body in these months due to skimpier clothes in the warmer weather. This would make them more aware of their body and in turn they examined themselves more often.
Researchers in Manchester combed through the records of 9,500 women who had been diagnosed with breast cancer in the North-West since 2001. They evaluated the date of diagnosis of these women.
These researchers were surprised to find that rates of breast cancer detection soared by about 25 per cent between April and July. It is to be noted that these women's cancers were not detected through the National Screening Programme which involves screening mammogram for those women who are aged more than 50 but were younger women who had gone to their general practitioner because of their own concerns about breast cancer.
This interesting study was lead by Professor Gareth Evans who is an oncologist and consultant in medical genetics at both Christie Hospital-and St Mary's Hospital in Manchester.
Source: Daily Mail; London (UK)
Feb 9, 2006
Linda Nolan Has Breast Cancer
Former pop singer and West End stage star Linda Nolan has been diagnosed with breast cancer. Nolan, who is 46 years old, who was diagnosed with breast cancer last week told reporters that it was shocking and is still trying to adjust the reality. Yet she is trying to be as positive as possible
Nolan said: "I know this is something that affects so many women and like them, all I can do is stay as positive as possible."
Spokeswomen for the singer confirmed that Nolan is due to start her treatment. Dublin-born. She said: "I can confirm that, yes, Linda has got breast cancer and she will be going into treatment."
Nolan made her stage debut at the age of four and the family act eventually achieved international success, touring Europe with Frank Sinatra, and with their own BBC TV Specials.
In her solo career, she has toured with Gene Pitney, and was voted Female Vocalist of the Year in 1990 for her cabaret show.
Nolan has been married to Brian Hudson, her manager, since 1981 and the couple live in London.
Feb 7, 2006
How Broccoli May Protect You From Cancer
Make broccoli a part of your everyday diet. This may protect you from cancer. A chemical found in vegetables such as broccoli, cauliflower and cabbage might boost DNA repair in cells that may have undergone damage. Previous research has shown a link between these foods and a reduced cancer risk. Now a new research is showing how these vegetables might decrease your risk of cancer.
These research findings are published in the latest issue of the British Journal of Cancer.
The protective effects of broccoli and other vegetables are attributable to the presence of a compound called I3C. During the normal process of growth and development DNA damages may occur. It is vital to repair these genetic defects and preventing it to pass to the daughter cells at the time of cell division.
The compound that is present in broccoli and other vegetables (13C) helps in the repair of damaged DNA. BRCA1 BRCA2, are genes that make proteins that help to repair DNA damage. These proteins helps to repair the genetic defects and prevent damaged genetic information being passed on to the next generation of cells. Those who have faulty genes like BRCA1 at BRCA2 may have a high of developing breast cancer and other types of the cancer.
Cancer cells usually have very low levels of BRCA proteins, so the scientists assume that higher levels might prevent cancer from developing. Researchers say that ability of I3C to boost the amount of BRCA proteins could explain their protective effects.
Feb 7, 2006
Eating Less Fat May Not Protect You From Cancer And Heart Disease
Eating less fat is not final solution cancer and heart disease as per findings from a recently published research. This new study has found that eating less fat later in life may not lower the risk of cancer and heart disease among older women. This is a disappointment for those who expected to have a greater benefit from a healthy diet.
These results come from a large study, sponsored by the government. A total of 48,835 women participated in this study. Researchers say that this is not the final decision regarding benefits of low fat diet.
Researchers argue that these women may have started this low-fat diet too late in their life to derive any benefit. Average age of patients participated in the study was 62 years. The researchers also point out that these women did not reduce the intake of fat as much as the diet demanded. Most of these women remained overweight during the course of the study, a major risk factor for cancer and heart problems.
This study, which has lasted eight years, showed no difference in the rate of breast cancer, colon cancer and heart disease among those who ate lower-fat diets and those who didn't.
Heart and cancer specialists said that thy were not very much surprised by the study results since scientific thinking on the role fats play in disease prevention has evolved since this study was designed. That is especially true when it comes to good and bad fats and heart disease.
Feb 6, 2006
Proteins That Work With Estrogen To Promote Breast Cancer
Some new proteins may work in partnership with estrogen to promote breast cancer. Researchers have identified a group of proteins that may work in partnership with estrogen to increase the risk of breast cancer. One such protein known as c-MYC is known to be associated with increased risk of cancer. However this is the first time a protein is the shown to interact with estrogen to increase the risk of breast cancer.
The study was conducted by researchers from Ohio State University Comprehensive Cancer Center. They are trying to answer the puzzling question of how estrogen can turn on some genes and turn off others during cancer progression.
Researchers, Ramana V. Davuluri and colleagues have found that estrogen may interact with seven different partner proteins to increase the risk of breast cancer. These new findings could lead to development of potential new drug targets and may now open the doors for new tests to identify breast-cancer patients with tumors that are likely to become resistant to hormonal therapies such as tamoxifen and aromatase inhibitors.
This new research is published in the recent issue of the journal Molecular Cell.
This study stands out of the crowd, because of the fact that the study used microarray technology and mathematical modeling to predict which cell proteins work with estrogen to contribute to breast cancer development, and then used more traditional experimental biology to verify one of the predictions.
Feb 1, 2006
How Breast Cancer Affects Your Job
Did your employer make reasonable accommodation for your breast cancer, while you were ongoing the treatment? If your answer is yes then you are in the majority. There is now information on this issue thanks to the research efforts of Dr. Reynard R. Bouknight and colleagues from Michigan State University in East Lansing. His study has shown that most women who are diagnosed with breast cancer return to work after completion of treatment of breast cancer. Dr. Bouknight says that it always helps to have an understanding and accommodating employer.
The study has found that 80 percent of women who have been diagnosed with breast cancer return to the same job she was having prior to the diagnosis. This indicates that these women are enjoying excellent health after completion of their treatment.
The study included 416 employed women, who have been diagnosed with breast cancer. These women were interviewed 12 and 18 months after being diagnosed with breast cancer.
Bouknight and colleagues found that Employer workplace accommodation was the most important factor that determined the return of the woman to the same job.
As per the perception of women who have been diagnosed with breast cancer, 87 percent of employers were willing to accommodate their treatment needs. Those women, who thought that their employers were not supportive, were less likely to return to work.
If you are interested in reading the whole study, you can find it the latest issue of the Journal of Clinical Oncology.
Jan 31, 2006
Cancer Care Varies From Place To Place
American health system provides good care for the cancer patients, however the type of care varies from place to place as per a new study. In a study published in the Journal of Clinical Oncology, the researchers say that, breast and colorectal cancer patients were given nearly all of the therapies recommended by experts.
This study, which was sponsored by the American Society of Clinical Oncology, examined the care of nearly 1,800 patients in Atlanta, Cleveland, Houston, Kansas City, Kan., and Los Angeles.
This study examined a broad range of therapies in two of the most common malignancies: 36 for breast cancer and 25 for colorectal cancer. Researchers found that doctors followed some guidelines more closely than others. Researchers have found that, among newly diagnosed breast cancer patients, 99% had their lymph nodes tested. But only 6% of patients who had higher risk of breast caner recurrence actually saw a radiation oncologist.
Researchers also noted wide variations from one hospital to another. For patients who have surgery for rectal cancer, experts say doctors should record whether tumor cells have spread to the lymph vessels or blood vessels. Within a single city, however, the percentage of patients whose doctors took this step was 13% to 99%, according to the study. The report's authors did not identify the city.
Jan 28, 2006
Passive Smoking, Breast Cancer Link
We have discussed the link between passive smoking and risk of breast cancer in this blog earlier. Now there is legal backing for this argument.
Regulators in California have recently ruled that secondhand smoke increases the risk for breast cancer in younger women. This is an unprecedented finding that could lead to tougher anti-smoking measures.
This ruling was approved by the state's Air Resources Board, which is well known nationally for its tough stance on limiting auto and diesel pollution. The board has unanimously approved a 1,200-page report from California Environmental Protection Agency scientists report citing that secondhand smoke increases the risk of breast cancer in younger women. The agency's findings challenged conventional scientific community which until recently considered the link between female smoking and breast cancer is based on scanty evidence.
"I think that if we don't embrace these new conclusions, we're doing a disservice to younger women," says Andrew Hyland, a research scientist at the Roswell Park Cancer Institute in Buffalo. "My prediction is that in the months to come, people will see the evidence and change their opinion."
By accepting the environmental protection agencies finding, the Air Resources Board officially lists secondhand smoke as a "toxic air contaminant" under state law. That begins a process that could lead to new restrictions in the state that already has the nation's toughest anti-smoking rules. Those could include reducing exposure in vehicles carrying children or in rental buildings where smoke drifts from apartments with smokers to non-smokers' units.
Jan 26, 2006
Doctor Apologizes For Mammogram Mistakes
Ar. Amjad Khan, who consultant radiologist is in deep trouble after missing diagnosis of breast cancer in 22 women for whom he was reading the mammograms. He was working at Trafford General Hospital, UK, when this incidence occurred. These 22 women were told much later that they had breast cancer in their mammograms that were taken previously.
An investigation was quickly enforced and experts combed through nearly 2,500 mammograms handled by the consultant at the two hospitals. They found that reading by this radiologist contained significant errors. About 176 patients were recalled to have repeat mammogram and among 28 were found to have some form of breast cancer. Twenty-one had been diagnosed with breast caner and one had treatable tumor. Dr Husien was suspended from working in the Trafford, Greater Manchester, after staff questioned his work.
In a statement released by Greater Manchester Strategic Health Authority on Thursday, Dr Husien said: "I deeply regret any distress or suffering experienced by patients and their relatives arising from this review.
Health managers have admitted some of the women could die because of mistakes made from April 2003.
Women undergo mammogram in an effort to find breast cancer early, and mistakes like this which defeats the purpose of mammogram can't be tolerated. The pain and misery caused to these 22 women who had significant delays in their breast cancer diagnosis can't be amply compensated by any action by the authorities.
Jan 25, 2006
Breast Cancer Increasingly Found At Early Stage
Diagnosis of early stage breast cancer shows a dramatic increase in UK since last five years. Reports say that incidence of earliest form of breast cancer, known as ductal carcinoma in situ, has increased to 3,800 compared to 2,910 that was found five years ago. Experts suggest that this increase is due to finding of a number of new cases due to mammogram screening and argue that these cases of breast cancer would have been missed, if mammogram screenings were not done.
Release of these numbers has particular significance. The figures were announced at the start of a worldwide study to investigate which of two breast cancer drugs, the old gold standard treatment tamoxifen or the new treatment, anastrozole, is better at preventing the dis-ease from returning in women who have already had DCIS.
This Ibis-2 study aims to recruit 10,000 women, 4,000 of who have been diagnosed with DCIS.
Concern about the rise in cases of DCIS has led some doctors to criticize the mammogram screening program for increasing anxiety and subjecting women to unnecessary treatment without extending their lives.
A study published in the British Medical Journal in 2003 said breast screening was contributing to a rise in the incidence of breast cancer and resulted in mastectomies that may have been unnecessary for the women and expensive for the health service.
Jan 22, 2006
Female Hormone Levels Don't Predict Breast Cancer
Higher blood level of a female hormone, namely estradiol, don't increase risk of developing breast cancer, as per findings from a new study.
Many studies in the past have suggested a positive relationship between higher levels of estradiol and increased risk of developing breast cancer in postmenopausal women. One study had found that raloxifen, which is selective estrogen receptor modulator (SERM) similar to commonly used tamoxifen may be a better option for postmenopausal women, who has higher levels of estradiol.
Mary S. Beattie, M.D., of the University of California in San Francisco, and colleagues examined the levels of sex hormones estradiol and testosterone, and sex hormone-binding globulin in the blood plasma of 135 postmenopausal women with breast cancer and 275 postmenopausal control women who had been treated with tamoxifen or placebo as part of a breast cancer prevention trial. The authors sought to determine whether sex hormone levels are associated with breast cancer risk, and whether breast cancer risk reduction varied by sex hormone level among women on tamoxifen, which is also a SERM.
Their results showed that levels of sex hormones were not associated with breast cancer risk in these women and cannot be used as a predictor for breast cancer risk or determine who would most benefit from tamoxifen treatment. Tamoxifen had the same effect on breast cancer risk in women with high and low levels of estradiol. The authors suggest that the study should be repeated in other populations with a high risk of developing breast cancer.
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Every year, more than 200,000 women are diagnosed with breast cancer in the United States. Breast cancer ranks second as the leading cause of cancer deaths in American women. Until recently breast cancer topped the list of leading causes of cancer deaths in women, but lately lung cancer has claimed the top position. If skin cancer is excluded, breast cancer is the commonest cancer among American women.
Breast Cancer Blog: From Medicineworld.org
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