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Diabetes Watch Blog: Transplanting Insulin Producing Cells In Diabetics

Return to Diabetes Blog Main Diabetes News Type-2 Diabetes  

Nov 29, 2005

Transplanting Insulin Producing Cells In Diabetics

Transplanting Insulin Producing Cells In Diabetics
Transplantation of insulin producing cells to diabetics is a hot topic among researchers. Now they are developing a new cell transplantation technique to restore the cells that produce insulin in patients with type 1 diabetes. This method is minimally invasive, with few complications.

These results are from a recent presentation at the Radiological Society of North America (RSNA).

"We used ultrasound guidance to inject donor cells into the portal vein of diabetic patients, which is accessed through the skin," said co-author Saravanan Krishnamoorthy, M.D., radiology resident at the University of Minnesota in Minneapolis. "This is a safe method of cell transplantation that could potentially become a same-day procedure."

In type-1 diabetes, the body does not produce insulin. This typically results from the destruction of insulin-producing islet beta cells in the pancreas. Insulin is necessary to metabolize sugar, which is the basic fuel that all cells need.

With this minimally invasive technique, donor islet cells are injected into diabetic patients so that the new, healthy islet cells can restore insulin production, essentially stopping the progression of the disease. The study included 13 patients with poorly controlled type-1 diabetes. Fifteen islet cell transplants were completed-two patients underwent two procedures to achieve correct needle placement.

"We used a steroid-free protocol to suppress the immune system, so that the body accepted the transplanted cells," Dr. Krishnamoorthy said. "We also developed a 'sandwich technique' to close the access site through the skin, where the islet cells are injected. The sandwich technique is so-called because of the layered applications of gelfoam and coil used to close the access site."

JoAnn      Return to Diabetes Blog Main


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Diabetes Watch Blog: Transplanting Insulin Producing Cells In Diabetics

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