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Heart Watch Blog: Actos Prevents Heart Attacks

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Dec 8, 2005

Actos Prevents Heart Attacks

Actos Prevents Heart Attacks
As you may very well know, patients with type-2 diabetes have a higher risk of developing coronary heart disease. Today I have some great news for such patients. Yes, the diabetic medication Actos (pioglitazone) is now known to reduce the recurrence of myocardial infarction in patients with diabetes and myocardial infarction. This is the first known oral diabetes drug has shown to prevent cardiovascular events.

Patients taking Actos (pioglitazone) also experienced considerable reductions in insulin resistance, C-reactive protein (a marker for inflammation) and blood pressure, all of which contribute to the overall risk for cardiovascular disease. Beyond its effects on blood glucose, it also keeps the blood vessels healthy precluding the hardening of the arteries.

In the main study, 5,238 patients with type 2 diabetes were randomly assigned to pioglitazone or placebo in addition to glucose-lowering drugs and other medications, and followed for an average of 34.5 months.

In these patients, pioglitazone significantly reduced the risk of fatal or recurrent non-fatal MI by 28% (a pre-specified endpoint) and significantly reduced the risk of acute coronary syndromes by 37% (part of a post hoc exploratory analysis).

Pioglitazone has shown to increases HDL cholesterol levels and LDL particle size, and decreases levels of triglycerides and inflammatory markers.


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Heart disease
About 13 million Americans (about 7 percent of the total population) suffer from coronary artery disease. Coronary artery disease is the leading cause of death in American men and women amounting a staggering 20 percent of all causes of death. About half of all deaths related to cardiovascular diseases occur from coronary artery disease. Through this heart watch blog we will have our humble contribution towards making men and women aware of the risks of heart diseases.

Heart Watch Blog: Actos Prevents Heart Attacks

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