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Heart Watch Blog: Insights Into Early Early Heart Development

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Jan 1, 2006

Insights Into Early Early Heart Development

Insights Into Early Early Heart Development
Researchers at The Burnham Institute for Medical Research have provided detailed insights into the early formation of the heart. A team lead by Dr. Rolf Bodmer found that two proteins, called Robo and Slit, are required for normal development of the heart and that malfunction of either of these proteins severely impacts the heart's structure, resulting in congenital heart defects. These findings were published in the recent issue of journal Current.

Congenital heart defects involve the malformation in one or more structures of the heart or blood vessels while the fetus is developing in the uterus. According to the American Heart Association, congenital heart disease affects about 35,000 infants each year, and claims the lives of "nearly twice as many children" annually in the United States "as die from all forms of childhood cancer". Symptoms may arise at birth, during childhood, and sometimes not until adulthood.

Working with Drosophilia melanogaster, also known as the fruitfly, the researchers showed that the Slit and Robo proteins accumulate in a specific alignment during the formation of the heart tube, a linear tube representing the primitive heart before its cells assume their rhythmical contractile functions. Proper alignment of the heart tube cells is critical for heart assembly and proper shape, or morphology. The researchers found that mutation or misexpression of these proteins leads to misalignment of the heart tube and results in observed heart defects.

Daniel      



Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Janet      


Heart disease
About 13 million Americans (about 7 percent of the total population) suffer from coronary artery disease. Coronary artery disease is the leading cause of death in American men and women amounting a staggering 20 percent of all causes of death. About half of all deaths related to cardiovascular diseases occur from coronary artery disease. Through this heart watch blog we will have our humble contribution towards making men and women aware of the risks of heart diseases.

Heart Watch Blog: Insights Into Early Early Heart Development

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