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Cancer blog: FDA Issues Warning For Herceptin Plus Chemotherapy Combination

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Nov 24, 2005

FDA Issues Warning For Herceptin Plus Chemotherapy Combination

FDA Issues Warning For Herceptin Plus Chemotherapy Combination
Genentec and FDA have issued a recent warning stating that combined use of herceptin (trastuzumab) and chemotherapy may significantly increase the risk of toxicity for the heart. Recent clinical trials have found that combination of herceptin with chemotherapy may improve disease free survival if used an adjuvant therapy in patients with early breast cancer, who over-expresses Her2 gene.

The findings from the trial (NSABP-B31 trial) reports that patients who received combination of herceptin and chemotherapy had 4.1 percent chance of developing congestive heart failure compared to just 0.8 percent chance in those who use chemotherapy alone. The final analysis of data is still ongoing.

The NSABP-B31 trial analyzed 2,043 women with early stage breast cancer over-expressing Her2 with combination of chemotherapy with or without herceptin and found about 50 percent reduction in the recurrence rate of breast cancer in women who received herceptin.

The message is clear: herceptin in combination with chemotherapy is an excellent choice for the right patient, but if used in low risk patients the risk may outweigh the benefit.

Janet      Return to Cancer Blog Main


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Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Heart watch blog: About 13 million Americans suffer from coronary artery disease. Coronary artery disease is the leading cause of death in American men and women amounting a staggering 20 percent of all causes of death. The tremendous responsibility of running a heart blog is entrusted to Daniel. He is creating blog posts with the help and support of other bloggers.

Janet      


Cancer
We do not know the exact cause of many cancers. Many cancers like leukemia have no apparent cause. Some other types of cancers like lung cancers have identifiable causes like smoking in most cases. Lung cancer can occur in those who have never smoked in their life. It is hard to know in these cases what is causing that patients lung cancer. Factors that increase the risk of development of cancer is known as risk factors for cancer. These risk factors may be modifiable like smoking where a person can exert control or un-modifiable factors like age and gender. Smoking can cause cancers of the lungs, mouth, throat, bladder, kidneys and several other organs.

Cancer blog: FDA Issues Warning For Herceptin Plus Chemotherapy Combination

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