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Cancer blog: Actis plans phase II study with colon cancer drug

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Oct 12, 2005

Actis plans phase II study with colon cancer drug

Actis plans phase II study with colon cancer drugActis Biologics Inc, a US-based pharmaceutical company, has received worldwide license for Angiozyme from Sirna and Chiron, who co-developed this novel compound with Actis. Angiozyme, a ribozyme based anti-cancer agent, has demonstrated activity against colon cancer in phase II clinical trials.

Sanjeev Saxena, president and CEO of Actis Biologics Inc., who is now in India told Pharmabiz, "The acquisition of Angiozyme accelerates the evolution of Actis Biologics into a clinical-stage oncology company in less than two years, and is in line with our business strategy of building a strong portfolio of targeted, novel, mechanism-based anti-cancer agents through the integration of internal discovery and in-licensing efforts." He added, "Actis is uniquely positioned to develop Angiozyme. The company has an experienced clinical development team, collaborations with global partners and a strong commitment to expedite the advancement of this molecule."

Angiozyme has been tested in over 90 advanced colorectal cancer patients in the US per FDA guidelines and has demonstrated anti-tumor activity. The company is planning to initiate additional phase II trials by the end of 2005.

Angiozyme is an anti-angiogenic compound designed to inhibit the growth of new blood supplies to tumors and prevent tumor growth and metastasis. Angiozyme is a phase IIb clinical product. Angiozyme is a ribozyme that specifically cuts up mRNA for VEGF-R1.

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We do not know the exact cause of many cancers. Many cancers like leukemia have no apparent cause. Some other types of cancers like lung cancers have identifiable causes like smoking in most cases. Lung cancer can occur in those who have never smoked in their life. It is hard to know in these cases what is causing that patients lung cancer. Factors that increase the risk of development of cancer is known as risk factors for cancer. These risk factors may be modifiable like smoking where a person can exert control or un-modifiable factors like age and gender. Smoking can cause cancers of the lungs, mouth, throat, bladder, kidneys and several other organs.

Cancer blog: Actis plans phase II study with colon cancer drug

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