Nov 21, 2005

Increase Fat Levels May Increase The Risk Of Colorectal Cancer

Adiponectin is an insulin insulin-sensitizing hormone secreted by fat cells. Esther K. Wei, Sc.D., of the Channing Laboratory at Brigham and Women's Hospital in Boston, and his colleagues have found that lower plasma levels of adiponectin, is associated with a increased risk of colorectal cancer.

Levels of adiponectin are inversely associated with body fat (that is, people with higher amounts of body fat tend to have lower circulating levels of adiponectin), and low levels of adiponectin are associated with insulin resistance and hyperinsulinemia.

The researchers studied plama adiponectin levels of 179 men in the Health Professionals Follow-up Study who developed colorectal cancer with those of 356 men who did not develop cancer.

men with the highest plasma adiponectin levels had a lower risk of developing colorectal cancer than men with the lowest plasma adiponectin levels. The inverse association remained even after adjusting for various measures of body fatness and other colorectal cancer risk factors. The authors conclude that more studies--particularly in women, who tend to have higher circulating levels of adiponectin than men--are needed to fully understand the relationship between adiponectin and carcinogenesis.

Sue      Return to Colon Cancer Blog Main

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Colorectal cancer
Colorectal cancer is a malignant tumor that arises from the inner wall of the large intestine or rectum. Colorectal cancer is the third commonest cancer diagnosed in the United States. Each year over 100,000 people are diagnosed with colorectal cancer in the United States. Most, of these cancers develop from growths in the colon called polyps. Removal of these polyps can prevent colon cancer.