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Colon cancer blog: CoFactor To Improve Colorectal Cancer Treatment

Colon cancer blog Colon cancer main Treatment of colon cancer  

Oct 25, 2005

CoFactor To Improve Colorectal Cancer Treatment

CoFactor To Improve Colorectal Cancer Treatment


Adventrx Pharmaceuticals, Inc. has presented positive pre-clinical data from a study with CoFactor in a colorectal cancer model at the American Association for Cancer Research (AACR) special conference in cancer research.

The study suggests that CoFactor in combination with 5-fluorouracil (5-FU) and oxaliplatin may be an effective chemotherapeutic regimen against colorectal cancer with higher efficacy and lower toxicity than the equivalent 5-FU, oxaliplatin and leucovorin regimen, informs a company release.

Adventrx's director of preclinical programmes Mark J. Cantwell and chief technical officer Joan M. Robbins, co-authored the study titled, "5,10-methylenetetrahydrofolate enhances anti tumour activity and reduces toxicity of 5-Fluorouracil plus oxaliplatin combination therapy in a colorectal cancer xenograph model."

"While combination therapy with 5-FU, leucovorin and oxaliplatin has shown improved clinical efficacy in treating colorectal cancer compared with 5-FU and leucovorin, optimum efficacy with oxaliplatin combination therapy might not be achieved in this combination due to multiple factors. CoFactor has already demonstrated anti tumour activity with an apparent safer toxicity profile in combination with 5-FU in Phase I and Phase II clinical trials in treatment of metastatic colorectal cancer," said Dr. Cantwell.

Sue      Return to Colon Cancer Blog Main


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Colorectal cancer
Colorectal cancer is a malignant tumor that arises from the inner wall of the large intestine or rectum. Colorectal cancer is the third commonest cancer diagnosed in the United States. Each year over 100,000 people are diagnosed with colorectal cancer in the United States. Most, of these cancers develop from growths in the colon called polyps. Removal of these polyps can prevent colon cancer.

Colon cancer blog: CoFactor To Improve Colorectal Cancer Treatment

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