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Colon cancer blog: Actis plans phase II study with colon cancer drug

Colon cancer blog Colon cancer main Treatment of colon cancer  

Sep 30, 2005

Actis plans phase II study with colon cancer drug

Actis plans phase II  study with colon cancer drugActis Biologics Inc, a US-based pharmaceutical company, has received worldwide license for Angiozyme from Sirna and Chiron, who co-developed this novel compound with Actis. Angiozyme, a ribozyme based anti-cancer agent, has demonstrated activity against colon cancer in phase II clinical trials.

Sanjeev Saxena, president and CEO of Actis Biologics Inc., who is now in India told Pharmabiz, "The acquisition of Angiozyme accelerates the evolution of Actis Biologics into a clinical-stage oncology company in less than two years, and is in line with our business strategy of building a strong portfolio of targeted, novel, mechanism-based anti-cancer agents through the integration of internal discovery and in-licensing efforts." He added, "Actis is uniquely positioned to develop Angiozyme. The company has an experienced clinical development team, collaborations with global partners and a strong commitment to expedite the advancement of this molecule."

Angiozyme has been tested in over 90 advanced colorectal cancer patients in the US per FDA guidelines and has demonstrated anti-tumor activity. The company is planning to initiate additional phase II trials by the end of 2005.

Angiozyme is an anti-angiogenic compound designed to inhibit the growth of new blood supplies to tumors and prevent tumor growth and metastasis. Angiozyme is a phase IIb clinical product. Angiozyme is a ribozyme that specifically cuts up mRNA for VEGF-R1.

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Colorectal cancer
Colorectal cancer is a malignant tumor that arises from the inner wall of the large intestine or rectum. Colorectal cancer is the third commonest cancer diagnosed in the United States. Each year over 100,000 people are diagnosed with colorectal cancer in the United States. Most, of these cancers develop from growths in the colon called polyps. Removal of these polyps can prevent colon cancer.

Colon cancer blog: Actis plans phase II study with colon cancer drug

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