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Colon cancer blog: Check colon tumor for Lynch syndrome

Colon cancer blog Colon cancer main Treatment of colon cancer  

Sep 25, 2005

Check colon tumor for Lynch syndrome

Check colon tumor for Lynch syndromeAll colon cancer tumors should be checked for the presence of Lynch syndrome, which is also known as a hereditary non-polyposis colon cancer (HNPCC).

These recommendations are the results of findings from a new study, which showed that one in 45 of surgically removed colon cancer tumors might have mutations for Lynch syndrome. This study was led by De la Chapelle from the Ohio State University and the results are published in the recent issue of the New England Journal of Medicine. The study involved testing of 1,066 newly diagnosed colorectal tumors and found the Lynch mutation in 23 of those tumor samples. Screening of first-degree relatives of these 23 patients with Lynch syndrome revealed an additional 52 people with undiagnosed Lynch syndrome.

Lynch syndrome runs in families and if some one has a Lynch mutation they have very high risk (close to 100 percent lifetime risk) of developing colorectal cancer. These people may also have increased risk of development of uterine and other types of cancer as well. If Lynch syndrome is identified other family members can be counseled regarding genetic testing and if found to be positive can take measures for early detection and prevention of development of colorectal cancer.

Sue      Return to Colon Cancer Blog Main


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Colorectal cancer
Colorectal cancer is a malignant tumor that arises from the inner wall of the large intestine or rectum. Colorectal cancer is the third commonest cancer diagnosed in the United States. Each year over 100,000 people are diagnosed with colorectal cancer in the United States. Most, of these cancers develop from growths in the colon called polyps. Removal of these polyps can prevent colon cancer.

Colon cancer blog: Check colon tumor for Lynch syndrome

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