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Medicineworld.org: New technology sharpens X-ray vision

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New technology sharpens X-ray vision




Scientists at the Paul Scherrer Institute (PSI) and the EPFL in Switzerland have developed a novel method for producing dark-field x-ray images at wavelengths used in typical medical and industrial imaging equipment.

Dark-field images provide more detail than ordinary x-ray radiographs and could be used to diagnose the onset of osteoporosis, breast cancer or Alzheimers disease, to identify explosives in hand luggage, or to pinpoint hairline cracks or corrosion in functional structures.



New technology sharpens X-ray vision
Traditional absorption image of chicken wing.

Credit: Franz Pfeiffer, EPFL/PSI

Up until this point, dark-field x-ray imaging mandatory sophisticated optics and could only be produced at facilities like the PSIs 300m-diameter, $200 million synchrotron. With the new nanostructured gratings described in this research, published online January 20 in Nature Materials, dark-field images could soon be produced using ordinary x-ray equipment already in place in hospitals and airports around the world.

Unlike traditional x-ray images, which show a simple absorption contrast, dark-field images capture the scattering of the radiation within the material itself, exposing subtle inner changes in bone, soft tissue, or alloys. The overall clarity of the images is striking. The improved sensitivity in measuring bone density and hairline fractures could help diagnose the onset of osteoporosis. Because cancer or plaque cells scatter radiation slightly differently than normal cells, dark-field x-ray images can also be used to explore soft tissue, providing safer early diagnosis of breast cancer or the plaques linked to Alzheimers disease.

Security screening equipment equipped with dark-field image capability could better identify explosives, whose micro-crystalline structures strongly scatter x-ray radiation. And because x-rays penetrate a material without damaging it, dark-field images could help reveal scattering-producing micro-cracks and corrosion in structures such as airplane wings or the hulls of boats.

Scientists have been working on dark-field x-ray images for a number of years, explains Franz Pfeiffer, a professor at EPFL and researcher at the PSI. Up until now these images have only been possible using sophisticated crystal optical elements. Crystal optics, however, only work for a single x-ray wavelength and thus are highly inefficient. Our new technique uses novel x-ray optical components, in the form of nanostructured gratings, that permit the use of a broad energy spectrum, including the standard range of energies in traditional x-ray equipment used in hospitals or airports, adds Christian David, Pfeiffers colleague at PSI. This opens up the possibility for adapting current imaging equipment to include dark-field imaging.

Pfeiffer plans to collaborate with the Center for Biomedical Imaging (CIBM), a joint center with the Universities of Lausanne and Geneva and their associated hospitals, to develop an adaptation for existing medical equipment. When combined with the phase contrast imaging technique that we developed in 2006, we now have the possibility of providing the same range of imaging techniques in broad-spectrum x-ray imaging that we do with visible light.


Posted by: Janet    Source




Did you know?
Scientists at the Paul Scherrer Institute (PSI) and the EPFL in Switzerland have developed a novel method for producing dark-field x-ray images at wavelengths used in typical medical and industrial imaging equipment. Dark-field images provide more detail than ordinary x-ray radiographs and could be used to diagnose the onset of osteoporosis, breast cancer or Alzheimers disease, to identify explosives in hand luggage, or to pinpoint hairline cracks or corrosion in functional structures.

Medicineworld.org: New technology sharpens X-ray vision

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