Medicineworld.org: Bright tumors, dim prospects
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Bright tumors, dim prospects
It doesn't matter how small or large it is, if a cervical tumor glows brightly in a PET scan, it's apt to be more dangerous than dimmer tumors. That's the conclusion of a new study of cervical cancer patients at Washington University School of Medicine in St. Louis.
Cervical tumor PET
Kidd and her colleagues, including scientists with the Siteman Cancer Center at Washington University and Barnes-Jewish Hospital, report their findings in an upcoming issue of the journal Cancer.
The scientists used FDG-PET, a widely available three-dimensional scanning technique. FDG-PET measures how rapidly tumors take up a radiolabeled glucose tracer (FDG) - high uptake results in a stronger or brighter signal in the scan. The scientists observed that the higher the standard uptake value (SUV) for FDG in the primary tumor, the greater the recurrence rate and the lower the survival rate of patients.
"FDG-PET is the most usually used PET scan," Kidd explains. "It's standard for patients to have this type of scan once diagnosed with cervical cancer. Oncologists use it to see the extent of the primary tumor and to look for tumors that have spread beyond the pelvis. But this study shows that the SUV obtained from FDG-PET can also tell physicians how well a patient will respond to therapy and should be part of the evaluation process."
A high SUV at diagnosis could signal that a patient should be followed more closely than usual after therapy to catch recurrences earlier, as per Kidd. She also indicates that eventhough the results suggest that patients with high SUV tumors may need more aggressive therapys, further clinical studies will be necessary to determine the best treatment in such cases.
In the current study, 287 patients with cervical cancer were treated with surgery, chemotherapy or radiation treatment following standard therapy protocols. At the time of diagnosis, the SUV of their primary tumor was obtained. Their cancers were also staged under standard guidelines, which rely largely on tumor size and involvement with surrounding tissues. The patients' cancers ranged from early (stage 1A2) to highly advanced (stage 4B).
The scientists showed that patients who had a high tumor SUV were more likely to have aggressive disease: They were likely to have malignant cells in their lymph nodes, persistent disease after initial therapy, recurrence of disease in the pelvis and lower survival rates. They also observed that tumor SUV did not depend on the tumor stage or volume - large tumors could have a relatively low SUV, and small tumors could have a high SUV.
The findings suggest that SUV is a more sensitive indicator of tumor aggressiveness than standard staging protocols. The study also demonstrated that SUV was better at predicting overall survival than the type of tumor or lymph node involvement, factors suspected to affect prognosis.
The patients were found to fall into three distinct risk groups. Those with the lowest SUV had a survival rate of 95 percent at five years, those in the middle SUV range had a 70 percent five-year survival rate, and those in the highest SUV range had a 44 percent five-year survival rate.
Because high SUV indicates that tumors take up glucose rapidly, the measurement may point to an important biological difference in these more aggressive cancers. "We're interested in finding out what causes that difference," Kidd says. "That could eventually lead to new methods for treating patients whose tumors have a high SUV."
Kidd presented the study's findings in Amsterdam in May at the meeting of the American Radium Society, the oldest society devoted to the study and therapy of cancer. The society gave Kidd one of three 2007 Young Oncologist Essay Awards and funded her travel to the conference.
Posted by: Janet Source
Did you know?
It doesn't matter how small or large it is, if a cervical tumor glows brightly in a PET scan, it's apt to be more dangerous than dimmer tumors. That's the conclusion of a new study of cervical cancer patients at Washington University School of Medicine in St. Louis. "We've seen that among patients with the same stage of cervical cancer, there will be some patients who don't respond to therapy as well as others," says lead author Elizabeth A. Kidd, M.D., a Barnes-Jewish Hospital resident in Washington University's Department of Radiation Oncology. "Our study suggests that PET (positron emission tomography) can reliably identify patients who have a poorer prognosis."
Medicineworld.org: Bright tumors, dim prospects
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