MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: Residual fetal cells in women may provide protection against breast cancer

Back to breast cancer blog Blogs list Cancer blog  


Subscribe To Breast Cancer Blog RSS Feed  RSS content feed What is RSS feed?

Residual fetal cells in women may provide protection against breast cancer




Fetal cells that persist in a womans body long after pregnancy a common occurrence known in scientific circles as fetal microchimerism in some cases may reduce the womans risk of breast cancer, as per scientists at Fred Hutchinson Cancer Research Center. The findings, reported in the Oct. 1 issue of Cancer Research, add to the Jekyll and Hyde characteristics of fetal microchimerism, or FMc, which has been found to be both detrimental and beneficial to womens health.



Residual fetal cells in women may provide protection against breast cancer

In this latest prospective study, researchers V.K. Gadi, M.D., Ph.D. and J. Lee Nelson, M.D., examined the blood of 82 women post-pregnancy, 35 of whom had had breast cancer. They looked for male DNA in the blood, presuming it was present due to a previous pregnancy. Fetal microchimerism (FMc) was found significantly more often in healthy women than women with a history of breast cancer, 43 percent versus 14 percent respectively. The researchers concluded that FMc may contribute to reduction of breast cancer based on the hypothesis that residual fetal cells may provide immune surveillance of cancerous cells in the mother. They caution that further studies are needed to confirm the theory.

To our knowledge, the current results provide the first indication that FMc could impart a protective effect against breast cancer, Gadi said.

Previous research into FMc, some of it performed at the Hutchinson Center, indicates that while the presence of fetal cells in women may confer immune protection and promote cell repair, such cells also may be harbingers of some autoimmune diseases.

Two observations provided a rationale for the study hypothesis of the potential beneficial role of fetal cells, as per the authors. It is well established that women who have given birth have a lower risk of breast cancer. And, allogeneic (from another individual) stem-cell transplants are used to treat a number of types of blood cancers by replacing a diseased immune system with a healthy one.

Additionally, fetal cells are usually found in the circulating blood of healthy women who have given birth. Fetal cells represent a naturally acquired source of allogeneic immune cells; in previous studies the prevalence of T, B, natural-killer (NK) and antigen-presenting cells of fetal origin in healthy women ranged from 30 percent to 70 percent, depending on the cell type.

The research was funded by the National Institutes of Health and Amgen Inc.


Posted by: Janet    Source




Did you know?
Fetal cells that persist in a womans body long after pregnancy a common occurrence known in scientific circles as fetal microchimerism in some cases may reduce the womans risk of breast cancer, as per scientists at Fred Hutchinson Cancer Research Center. The findings, reported in the Oct. 1 issue of Cancer Research, add to the Jekyll and Hyde characteristics of fetal microchimerism, or FMc, which has been found to be both detrimental and beneficial to womens health.

Medicineworld.org: Residual fetal cells in women may provide protection against breast cancer

BREAST CANCER MAIN| Home| Breast cancer news| Common terms| Breast cancer treatment| Breast cancer treatment by stage| Mammogram and breast cancer screening| Surgical treatment of breast cancer| Chemotherapy of breast cancer| Chemo drugs used in breast cancer| Doxorubicin| Cyclophosphamide| Methotrexate| Hormonal therapy of breast cancer| Radiation therapy of breast cancer| Monoclonal therapy| High dose chemotherapy for breast cancer| Recurrent breast cancer| Bisphosphonates and breast cancer| Pregnancy and breast cancer| Risk factors for breast cancer| Risk details| My risk| Comprehensive breast cancer information| Breast cancer statistics| African Americans and breast cancer| Ashkenazi and breast cancer| Asians| Hispanic| Men| Native Americans| Older women and breast cancer| Younger women| Pregnant women and breast cancer| BRCA|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.