3-D Radiation And Feeding-tube Use

Eventhough current surgical techniques and multi-modality therapy regimens allow organ preservation for a growing number of patients with head and neck cancers, remaining dependent on a feeding tube after therapy is a major problem for these patients. An analysis by Fox Chase Cancer Center scientists sought to identify which therapy-related factors are more likely to avoid feeding-tube dependency.

"Three-dimensional therapy planning appears to have a significant impact on improving quality of life by reducing feeding tube dependency," said medical intern Linna Li, M.D., who presented the results today at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia.

The retrospective study analyzed therapy records since 1997 for patients receiving definitive radiation treatment--with or without surgery and chemotherapy--for squamous-cell carcinomas of the throat, including oropharynx, hypoharynx and larynx. Definitive radiotherapy is a curative course of radiation therapy designed to eradicate a known cancer.

Eligible patients--a total of 90--had either stage III or IV cancer with no previous surgery or radiation treatment in the head and neck region and remained cancer-free 18 months or more after completing radiation treatment. The majority of patients were men (82 percent) who had oropharyngeal cancer (63 percent) with a T stage (extent of primary tumor, including size, at diagnosis) of either T2 or T3 (71 percent).

Only 44 percent had neck surgery, but 58 percent had concurrent chemotherapy. Only 10 percent had radiation therapys using altered fractionation schemes. Sixty percent had two-dimensional therapy planning for radiation treatment while 40 percent had three-dimensional CT-based therapy planning.

A feeding tube was placed in 56 of these 90 patients (62 percent): 19 before radiation treatment; 26 during radiation treatment; and 11 after radiation treatment. Two-thirds of the men had the feeding tube removed during the follow-up period, with only 15 percent retaining the tube after 18 months.

"In analyzing the factors linked to feeding tube dependency at 18 months, only the higher T stage and 2-D therapy planning were independent predictors," Li said. "Of the 54 patients who had 2-D therapy planning, 20 were feeding-tube dependent at 18 months in comparison to just five of the 36 who had 3-D therapy planning. Of the three patients who had intensity-modulated radiation treatment instead of conventional radiation, none were feeding-tube dependent.

"Three-dimensional therapy planning can help patients avoid feeding tube dependency," Li concluded. "Possible explanations may be improved tumor targeting with smaller areas receiving high doses or more evenly distributed doses in large radiation fields".


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