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Medicineworld.org: Prolonged Anthracycline Therapy Reduces Heart Problems

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Prolonged Anthracycline Therapy Reduces Heart Problems

Prolonged Anthracycline Therapy Reduces Heart Problems
Stretching out a dose of chemotherapy over six or more hours may reduce the risk of heart problems caused by certain usually used cancer drugs, as per a new review of recent research.

Anthracycline drugs like daunorubicin and doxorubicin are used to treat a number of types of solid tumors and blood cancers such as leukemias in adults and children.

Anthracycline treatment can be very successful at controlling cancer, but heart damage caused by anthracycline therapy is a considerable and serious problem, said Dr. Elvira van Dalen of the Emma Childrens Hospital in the Netherlands.

She and her colleagues observed that the rates of heart failure among adult patients receiving anthracycline treatment were significantly lower when the patients had an infusion of the drug that lasted six or more hours, in comparison to shorter infusions times.

In five studies involving 557 patients, the longer therapy cut the risk of heart failure by nearly 75 percent in comparison to the risk in patients who received the short therapy.

van Dalen said the prolonged dose of six hours or more might be justified if a patient is at high risk of heart damage or needs a high cumulative dose of the chemotherapy.

The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.

In some of the studies, the prolonged dose also reduced the risk of less severe problems such as weakened heart function. Patients had the same chance of survival and tumor shrinkage whether they received the long or short therapies, the Cochrane scientists found.

It should be emphasized that the majority of the patients included in these studies were adults with advanced solid tumors, van Dalen and his colleagues said, noting that there are few good studies about the length of anthracycline therapy in children.

Among the children in the study, there was no difference in heart damage between the long and short therapys and no information on survival and tumor shrinkage was available, van Dalen said.

Recent studies have shown that the toxic heart effects of anthracycline treatment can have lasting effects on childrens health. Dr. Stephen Lipshulz, a pediatric cancer specialist at the University of Miami, said childhood cancer survivors may be at significant risk of serious cardiovascular problems at a much younger age," than scientists believed a few years ago.

Lipshulzs work suggests a number of childhood cancer survivors suffer from enlarged hearts and prematurely hardened arteries, due at least in part from their chemotherapy. Its alarming that weve found such dramatic heart damage and blood vessel risk in some survivors who are just 10 or 15 years from therapy, he said.


Posted by: Janet    Source




Did you know?
Stretching out a dose of chemotherapy over six or more hours may reduce the risk of heart problems caused by certain usually used cancer drugs, as per a new review of recent research. Anthracycline drugs like daunorubicin and doxorubicin are used to treat a number of types of solid tumors and blood cancers such as leukemias in adults and children.

Medicineworld.org: Prolonged Anthracycline Therapy Reduces Heart Problems

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