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Medicineworld.org: Hormone shows promise in reversing Alzheimer's disease

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Hormone shows promise in reversing Alzheimer's disease




Saint Louis University scientists have identified a novel way of getting a potential therapy for Alzheimer's disease and stroke into the brain where it can do its work.

"We found a unique approach for delivering drugs to the brain," says William A. Banks, M.D., professor of geriatrics and pharmacological and physiological science at Saint Louis University. "We're turning off the guardian that's keeping the drugs out of the brain".

The brain is protected by the blood-brain barrier (BBB), a gate-keeping system of cells that lets in nutrients and keeps out foreign substances. The blood-brain barrier passes no judgment on which foreign substances are trying to get into the brain to treat diseases and which are trying to do harm, so it blocks them without discrimination.



Hormone shows promise in reversing Alzheimer's disease

"The problem in treating a lot of diseases of the central nervous system such as Alzheimer's disease, HIV and stroke is that we can't get drugs past the blood-brain barrier and into the brain," says Banks, who also is a staff doctor at Veterans Affairs Medical Center in St. Louis.

"Our new research shows a way of getting a promising therapy for these types of devastating diseases to where they need to be to work".

The treatment known as PACAP27 -- is a hormone produced by the body that is a general neuro-protectant. PACAP stands for pituitary adenylate cyclase-activating polypeptide. "It is a general protector of the brain against a number of types of insult and injury," Banks says.

He compares a specific guarding mechanism in the BBB -- efflux pumps to bouncers at exclusive nightclubs. While they welcome those on the approved guest list, they look for trouble-makers trying to crash the party, refuse to let them in and evict them if they do get in.

The researchers isolated the particular gatekeeper than evicts PACAP27. Then they designed an antisense, a specific molecule that turned off the impediment.

"We went after the guard and essentially told him to go on break for a while so PACAP27 could get into the brain," Banks says.

They used mouse models of Alzheimer's disease and stroke to test what would happen if PACAP27 could get into the brain.

"We reversed the symptoms of the illnesses," Banks says. "The mice that had a version of Alzheimer's disease became smarter and in the stroke model, we reduced the amount of damage caused by the blockage of blood to the brain and improved brain recovery".

Simply turning off the gatekeeper that kept PACAP27 out of the brain allowed enough of the hormone that already is in the body to get inside the brain, where it effectively treated strokes. However, the mice that had a version of Alzheimer's disease needed both an extra dose of PACAP27 and the antisense that turned off the gatekeeper to improve learning.

"These findings are significant for three reasons. We have found a treatment that reverses symptoms of Alzheimers's disease and stroke in a mouse model. We have isolated the particular roadblock that keeps the therapy from getting into the brain. And we have found a way to finesse that obstacle so the medicine can get into the brain to do its work," Banks says. "This could have implications in treating a number of diseases of the central nervous system".

The findings were reported in the Nov. 12 early online issue of the Journal of Cerebral Blood Flow & Metabolism


Posted by: Daniel    Source




Did you know?
Saint Louis University scientists have identified a novel way of getting a potential therapy for Alzheimer's disease and stroke into the brain where it can do its work. "We found a unique approach for delivering drugs to the brain," says William A. Banks, M.D., professor of geriatrics and pharmacological and physiological science at Saint Louis University. "We're turning off the guardian that's keeping the drugs out of the brain".

Medicineworld.org: Hormone shows promise in reversing Alzheimer's disease

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