From Medicineworld.org: How Clinical Trial Participants Perform?
Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.
Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.
Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.
Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.
Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.
Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.
How Clinical Trial Participants Perform?
The finding was published against a backdrop of debate about drug trials for popular pain-relievers and about whether trial results can be safely applied to an entire population. "These results challenge the assertion that the results of RCTs (randomized controlled trials) are not applicable to usual clinical practice," report the authors, who say this review is the most comprehensive of its kind conducted to date.
A randomized clinical trial is considered the "gold standard" of medical research because it is the best way to make sure that the only difference between the groups that are compared is the therapy they receive. Patients are assigned to each group randomly in order to increase the probability that differences between the groups can be attributed only to the therapy under study.
Critics, however, say the rigorous standards for inclusion in trials and the nature of those who conduct and participate in them mean that when a new drug or therapy is applied to a general population, the results might be different.
A recent article in the prestigious journal The Lancet suggested that clinical trials cannot be expected to be relevant to all patients with the same conditions for many reasons, such as selecting trial participants who are in better overall health, excluding people who have conditions in addition to the one being studied and the reality that in a general population patients will not always act according to doctors' instructions.
In the new study, scientists led by Gunn Elisabeth Vist of the Norwegian Health Services Research Centre, systematically identified and reviewed 55 studies involving a total of more than 31,000 patients who were treated in randomized clinical trials and more than 20,000 patients who were treated outside of them.
"The bottom line is that the effects of therapys appear most of the time to be similar inside and outside of trials, and participation in trials doesn't appear to be associated with greater risk than getting the same therapy outside of a trial," reports Andrew Oxman, one of the review authors".
The review appears in the recent issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.
What is new in this review is that the scientists compared outcomes of study participants with those who did not participate in studies but received similar therapys.
In 91 comparisons, the scientists found no statistically significant differences. Ten comparisons showed better outcomes for patients within the trial, and four comparisons showed worse outcomes for them. One important limitation of the review is that the results are based mainly on "cohort comparisons" that fall short of the most rigorous randomized controlled trials, but Vist says patients similar to the controlled trial participants can expect similar outcomes if given the same therapy outside of a trial.
Oxman himself believes that clinical trials frequently may offer the benefit of better care, despite their finding that there commonly is no difference in outcomes. "Typically, when you're cared for in a trial, you're cared for according to a protocol and you often get better follow-up than you get in routine practice," he says. "In addition, health care professionals who participate in trials may be more up-to-date and practice more in accordance with best evidence".
According to a December 2004 survey of 1,000 adults conducted by the non-profit Center for Information and Study on Clinical Research Participation and Opinion Dynamics Corporation, two-thirds of Americans think that clinical research studies are "very safe" or "somewhat safe." More than half of respondents also said they would have greater trust in clinical research information if the results were disclosed on a public Web site.
"The primary reason people participate in clinical trials is to gain access to new therapies that may offer therapy where none exists currently, or that offers benefits over currently available therapys," says CISCRP chairman Ken Getz. "Another top reason people participate is to help advance medical knowledge. They participate because they feel doing so may have an impact on other people's lives."
Did you know?
People who participate in randomized controlled studies to test new therapies seem to fare no better or no worse than those who receive the same care outside of such studies, a new review of research has found. The finding was published against a backdrop of debate about drug trials for popular pain-relievers and about whether trial results can be safely applied to an entire population. "These results challenge the assertion that the results of RCTs (randomized controlled trials) are not applicable to usual clinical practice," report the authors, who say this review is the most comprehensive of its kind conducted to date.
Medicineworld.org: How Clinical Trial Participants Perform?
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.