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From Medicineworld.org: Test For Patients With Colorectal Cancer

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Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Janet      

Test For Patients With Colorectal Cancer


Test For Patients With Colorectal Cancer
University of Chicago scientists have licensed a genetic test that determines which patients are likely to have a serious adverse reaction to irinotecan hydrochloride (Camptosarandreg;), a key component of the standard first-line therapy for advanced cancers of the colon and rectum, to Mayo Clinic.

Until now, the UGT1A1 test has only been available to patients enrolled in studies at the University of Chicago. Third Wave had received FDA approval for its UGT1A1 test kit in August, but the test had still not been made available to patients.

Through this licensing agreement, Mayo Clinic's reference laboratory, Mayo Medical Laboratories (MML), will make the test available to patients nationwide, starting this month.

The UGT1A1 test was developed and patented by Mark J. Ratain, MD, the Leon O. Jacobson Professor of Medicine and Chairman of the Committee on Clinical Pharmacology and Pharmacogenomics at the University of Chicago, and his colleagues. It gives doctors advance knowledge of an individual's risk for toxicity from irinotecan by revealing whether patients have one of two common versions of a gene that encodes for a protein involved in the metabolism of irinotecan.

"Eventhough most patients tolerate the drug quite well, some patients are genetically predisposed to severe side effects from irinotecan therapy," said Ratain. "The UGT1A1 test enables us to know in advance which patients are at risk. Those patients could be given reduced doses of irinotecan or other chemotherapy drugs".

This kind of customized dosing based on a person's genetic makeup is known as pharmacogenomics and is at the forefront of 21st century medicine. The UGT1A1 test is part of a growing list of pharmacogenomic tests designed to help physicians personalize therapy options.

"Precise dosing is extremely important for cancer chemotherapy because a number of of these drugs are most effective at the highest possible dose, yet they are also quite toxic," said Ratain. "But finding the right dose is difficult because patients vary radically and unpredictably in how they respond to these drugs. Our goal is to determine how an individual's genetic makeup controls the ways he or she responds to these drugs--how the medications are absorbed, distributed in the body, broken down, and eliminated--and to use that knowledge to determine the best possible dose for each patient".

"Our early studies with irinotecan demonstrated that the highly variable toxicity was related to variability in the drug's metabolism," he said. "We subsequently found that patients with two copies of one version of the UGT1A1 gene had few side effects at the standard dosage. Patients with only one copy of this version had more difficulty, and patients with two copies of the alternative version were at high risk for severe side effects.

"So relying on one standard dose meant that some of those patients received sub-therapeutic doses of irinotecan and others received more than they could manage. We envision that dosing based on the UGT1A1 test will have the dual advantage of reducing side effects and increasing benefit of this important drug".

Because of this study, the FDA, on June 7, 2005, mandatory amendment of the package insert for Camptosarandreg; to include a warning that patients with a particular UGT1A1 genotype should receive a lower starting dose.

"With the growing interest in individualizing drug treatment, FDA's approval of this assay provides physicians and patients with important information on the proper dosage of drugs metabolized and cleared from the body by the UGT1A1 pathway," said Lawrence Lesko, PhD, Director of the FDA's Office of Clinical Pharmacology and Biopharmaceutics in the Center for Drug Evaluation and Research in a press release issued when the FDA approved UGT1A1 testing in August.

"Information on the UGT1A1 genotype can be an integral part of drug labels," he added, "And will guide health professionals on how to dose medications such as irinotecan".

Colorectal cancer is the fourth most usually diagnosed cancer in the U.S., with more than 145,000 new cases per year in the U.S. It accounts for nearly 60,000 deaths per year in the U.S. alone.

The application of this test for patients with colon and rectal cancer, however, may only be the beginning. Irinotecan also is being tested and used for other GI cancers as well as lung and breast carcinoma.

The Department of Laboratory Medicine and Pathology at Mayo Clinic maintains an active diagnostic test development program. These activities also incorporate discoveries made elsewhere, such as the UGT1A1 patents from the University of Chicago. Mayo Clinic offers these proven diagnostic technologies to more than 5,000 healthcare institutions around the world through MML.

Mayo acquired an exclusive license to the UGT1A1 technology from the University of Chicago, which includes the right to sub-license the test, and will actively pursue agreements with other academic medical centers, laboratories, diagnostic test companies, and pharmaceutical companies to ensure that patients everywhere have access to this important screening test. Mayo recently sub-licensed the rights under the University of Chicago patent to Third Wave Technologies.


Source: University of Chicago Hospitals


Did you know?
University of Chicago scientists have licensed a genetic test that determines which patients are likely to have a serious adverse reaction to irinotecan hydrochloride (Camptosarandreg;), a key component of the standard first-line therapy for advanced cancers of the colon and rectum, to Mayo Clinic.

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