MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: Androgen Therapy To Slow Progress Of Alzheimer's Disease

Back to neurology news Blogs list Cancer blog  


Subscribe To Neurology News RSS Feed  RSS content feed What is RSS feed?

Androgen Therapy To Slow Progress Of Alzheimer's Disease

Androgen Therapy To Slow Progress Of Alzheimer's Disease
Experiments on mouse models of Alzheimer's disease (AD) suggest that therapy with male sex hormones might slow its progression. The findings, reported in the December 20 issue of The Journal of Neuroscience, provide new insight into the relationship between testosterone loss and AD, which affects 4.5 million Americans.

Senior author Christian Pike, PhD, of the University of Southern California (USC), with colleagues at USC and the University of California, Irvine, sought to better understand the role hormones play in aging and disease. Recent studies had already established a link between testosterone loss in men and AD due to natural aging.

The research team established a connection between low testosterone and elevated beta-amyloid (A), a protein that accumulates abnormally in AD patients. This finding, they say, suggests that testosterone depletion in aging men may be a risk factor for AD by promoting accumulation of A in the brain. Testosterone, the primary male sex hormone, is one in a group of related steroid hormones referred to as androgens. Recent studies suggest that androgens may lower A levels.

"This study raises the possibility that androgen replacement treatment might lower the risk for Alzheimer's, but this is far from proven," says Sam Gandy, MD, PhD, chair of the Alzheimer's Association's Medical and Scientific Advisory Council and director of the Farber Institute for Neurosciences at Thomas Jefferson University. "Because testosterone is rapidly converted to estrogen after entry into neurons, the new data are logical, and they dovetail well with historical data".

Using a mouse model of AD, in which three genes had been altered, scientists reviewed how experimental manipulation of sex hormones affected the progress of the disease. Scientists removed the testes of young adult male mice and over several months, treated some with a testosterone hormone and others with a placebo.

After the therapy period, memory-related behavior and measures of Alzheimer-like pathology were measured in the different groups of mice. The castrated models that received the placebo showed poor working memory and high brain levels of A. However, both A accumulation and cognitive decline were prevented in mice treated with the hormone treatment.

"Eventhough the results of the study predict that androgen treatment has the potential to reduce the risk of AD in at least some men," Pike said, "clinical studies will be mandatory to determine when and how to use androgen treatment".


Posted by: Daniel    Source




Did you know?
Experiments on mouse models of Alzheimer's disease (AD) suggest that therapy with male sex hormones might slow its progression. The findings, reported in the December 20 issue of The Journal of Neuroscience, provide new insight into the relationship between testosterone loss and AD, which affects 4.5 million Americans.

Medicineworld.org: Androgen Therapy To Slow Progress Of Alzheimer's Disease

Acute bacterial meningitis| Alzheimer's disease| Carpal tunnel syndrome| Cerebral aneurysms| Cerebral palsy| Chronic fatigue syndrome| Cluster headache| Dementia| Epilepsy seizure disorders| Febrile seizures| Guillain barre syndrome| Head injury| Hydrocephalus| Neurology| Insomnia| Low backache| Mental retardation| Migraine headaches| Multiple sclerosis| Myasthenia gravis| Neurological manifestations of aids| Parkinsonism parkinson's disease| Personality disorders| Sleep disorders insomnia| Syncope| Trigeminal neuralgia| Vertigo|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.