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Medicineworld.org: Effective new treatment for schizophrenia

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Effective new treatment for schizophrenia




Schizophrenia is one of the most debilitating of the major psychiatric disorders, and is also one of the most difficult to treat. Eventhough numerous antipsychotic therapys are available, they can cause significant side effects and a number of patients experience only a partial relief of their symptoms and up to 30% no relief at all. In a new study scheduled for publication in the December 15th issue of Biological Psychiatry, Marder and his colleagues examined the efficacy and safety of a new psychotropic agent for the therapy of schizophrenia in a 6-week, randomized, placebo-controlled trial.



Effective new treatment for schizophrenia

The authors studied paliperidone extended-release (ER) tablets, an investigational drug which orally delivers the active metabolite of the drug risperidone, which is an already established efficacious antipsychotic. The authors recruited 444 patients who were experiencing an acute episode of schizophrenia and, after evaluating the severity of their symptoms, administered one of four therapys for 6 weeks: 6 mg or 12 mg/day of paliperidone ER, 10 mg/day of olanzapine (the active comparator), or placebo. During the six weeks of therapy, the researchers monitored the patients for side effects and assessed their symptom improvement.

Dr. Stephen Marder, senior author on the paper, explains the findings: This double-blind study observed that two doses of paliperidone extended release tablets were more effective than placebo for treating the symptoms of acute schizophrenia. Patients receiving the most effective dose of paliperidone (6 mg) also demonstrated improvements in their social functioning. Jeffrey A. Lieberman, M.D., Chairman of the Department of Psychiatry at Columbia University and Director of the New York State Psychiatric Institute, comments, This study demonstrates the efficacy of the 9-hydroxy metabolite of risperidone that has antipsychotic efficacy and an acceptable safety profile which provides psychiatry experts with yet another therapy option. It has practical advantages with its long half life, duration of action and extended release formulation. Dr. Lieberman cautions though that this finding is not a novel or breakthrough therapy and does not provide major differences or advantages over existing therapys. Additional studies are currently underway to further evaluate the long-term (up to one year) efficacy and safety of paliperidone ER in the therapy of schizophrenia.


Posted by: JoAnn    Source




Did you know?
Schizophrenia is one of the most debilitating of the major psychiatric disorders, and is also one of the most difficult to treat. Eventhough numerous antipsychotic therapys are available, they can cause significant side effects and a number of patients experience only a partial relief of their symptoms and up to 30% no relief at all. In a new study scheduled for publication in the December 15th issue of Biological Psychiatry, Marder and his colleagues examined the efficacy and safety of a new psychotropic agent for the therapy of schizophrenia in a 6-week, randomized, placebo-controlled trial.

Medicineworld.org: Effective new treatment for schizophrenia

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