Drug Interactions In Imatinib Therapy from medicineworld.org

Drug Interactions In Imatinib Therapy


Drugs that increase plasma Imatinib concentration
Drug	Action suggested
Aprepitant	Monitor for Imatinib adverse events
Clarithromycin	Monitor for Imatinib adverse events
Erythromycin	Monitor for Imatinib adverse events
Itraconazole	Monitor for Imatinib adverse events
Ketoconazole	Monitor for Imatinib adverse events
Vericonazole	Monitor for Imatinib adverse events


Drugs that decrease plasma Imatinib concentration
Drug	Action suggested
Carbamazepine	Increase Imatinib dose by 50% and monitor for clinical response
Dexamethasone	Increase Imatinib dose by 50% and monitor for clinical response
Phenobarbital	Increase Imatinib dose by 50% and monitor for clinical response
Phenytoin	Increase Imatinib dose by 50% and monitor for clinical response
Rifabutin	Increase Imatinib dose by 50% and monitor for clinical response
Rifampin	Increase Imatinib dose by 50% and monitor for clinical response


Drugs that may have increased plasma levels when used with Imatinib
Drug	Action suggested
Cyclosporin	Monitor cyclsporin drug levels
Eletriptan	Do not give this drug within 72 hours of Imatinib intake
Simvastatin	Monitor for simvastatin side effects
Warfarin	Monitor INR, monitor for bleeding

Did you know?
Entry of Imatinib (gleevec) has revolutionized the treatment of chronic myeloid leukemia (CML). More are more patients with a diagnosis of CML are now on imatinib (gleevec). Most of these patients do very well on imatinib (gleevec), however some patients never respond to imatinib (gleevec) and some other patients initially respond to this drug but later develop resistance to this drug.


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