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Medicineworld.org: Drug Interactions In Imatinib Therapy

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Drug Interactions In Imatinib Therapy

Drug Interactions In Imatinib Therapy


 
Drugs that increase plasma Imatinib concentration
Drug Action suggested
Aprepitant Monitor for Imatinib adverse events
Clarithromycin Monitor for Imatinib adverse events
Erythromycin Monitor for Imatinib adverse events
Itraconazole Monitor for Imatinib adverse events
Ketoconazole Monitor for Imatinib adverse events
Vericonazole Monitor for Imatinib adverse events
 
 
Drugs that decrease plasma Imatinib concentration
Drug Action suggested
Carbamazepine Increase Imatinib dose by 50% and monitor for clinical response
Dexamethasone Increase Imatinib dose by 50% and monitor for clinical response
Phenobarbital Increase Imatinib dose by 50% and monitor for clinical response
Phenytoin Increase Imatinib dose by 50% and monitor for clinical response
Rifabutin Increase Imatinib dose by 50% and monitor for clinical response
Rifampin Increase Imatinib dose by 50% and monitor for clinical response
 
 
Drugs that may have increased plasma levels when used with Imatinib
Drug Action suggested
Cyclosporin Monitor cyclsporin drug levels
Eletriptan Do not give this drug within 72 hours of Imatinib intake
Simvastatin Monitor for simvastatin side effects
Warfarin Monitor INR, monitor for bleeding




Did you know?
Entry of Imatinib (gleevec) has revolutionized the treatment of chronic myeloid leukemia (CML). More are more patients with a diagnosis of CML are now on imatinib (gleevec). Most of these patients do very well on imatinib (gleevec), however some patients never respond to imatinib (gleevec) and some other patients initially respond to this drug but later develop resistance to this drug.

Medicineworld.org: Drug Interactions In Imatinib Therapy

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