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Medicineworld.org: Veggies may protect you from cancer

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Veggies May Protect You From Cancer

veggies may protect you from cancer
Need another reason to eat your vegetables? New research shows that some of them contain chemicals that appear to enhance DNA repair in cells, which could lead to protection against cancer development, say Georgetown University Medical Center researchers.

As per a research findings reported in the British Journal of Cancer (published by the research journal Nature) the scientists show that in laboratory tests, a compound called indole-3-carinol (I3C), found in broccoli, cauliflower and cabbage, and a chemical called genistein, found in soy beans, can increase the levels of BRCA1 and BRCA2 proteins that repair damaged DNA.

Eventhough the health benefits of eating your vegetables-particularly cruciferous ones, such as broccoli-aren't especially new, this study is one of the first to provide a molecular explanation as to how eating vegetables could cut a person's risk of developing cancer, an association that some population studies have observed, says the study's senior author, Eliot M. Rosen, MD, PhD, professor of oncology, cell biology, and radiation medicine at Georgetown's Lombardi Comprehensive Cancer Center.

"It is now clear that the function of crucial cancer genes can be influenced by compounds in the things we eat," Rosen says. "Our findings suggest a clear molecular process that would explain the correlation between diet and cancer prevention."

In this study, Rosen exposed breast and prostate cancer cells to increasing doses of 13C and genistein, and found that these chemicals boosted production of BRCA1, as well as its sister repair protein, BRCA2. Mutations in either of these genes can lead to development of breast, prostate and ovary cancers.

Since decreased amounts of the BRCA proteins are seen in cancer cells, higher levels might prevent cancer from developing, Rosen says, adding that the ability of I3C and genistein to increase production of BRCA proteins could explain their protective effects.

The study was funded by the Susan G. Komen Breast Cancer Foundation and the National Cancer Institute and co-authors include Drs. Saijun Fan, MD, PhD, Qinghui Meng, MS, Karen Auborn, PhD, and Timothy Carter, PhD.



Source: Georgetown University Medical Center




Did you know?
Need another reason to eat your vegetables? New research shows that some of them contain chemicals that appear to enhance DNA repair in cells, which could lead to protection against cancer development, say Georgetown University Medical Center researchers. As per a research findings reported in the British Journal of Cancer (published by the research journal Nature) the scientists show that in laboratory tests, a compound called indole-3-carinol (I3C), found in broccoli, cauliflower and cabbage, and a chemical called genistein, found in soy beans, can increase the levels of BRCA1 and BRCA2 proteins that repair damaged DNA.

Medicineworld.org: Veggies may protect you from cancer

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