Protein targets antibiotic-resistant bacteria

A new type of protein discovered by Queens University scientists may be useful in developing therapys for antibiotic-resistant bacteria, such as those that cause food poisoning and typhoid.

By solving the structure and activity of the protein called YihE or RdoA a team of professors and students from the departments of Biochemistry and Microbiology & Immunology has opened up possibilities for new drug development.

Our group is the first to solve the structure and to begin to understand the function of this particular protein, says Dr. Nancy Martin (Microbiology & Immunology), who coordinated the study with Dr. Zongchao Jia (Biochemistry). It turns out to be a potentially good target in a wide range of bacteria that cause infectious diseases. Because of the increasing number of antibiotic-resistant strains of a number of different types of bacteria, such as salmonella, she notes, new approaches to antibiotic treatment are needed.

The Queens findings appear in the on-line edition of the journal Molecular Microbiology.

Also on the team, from Biochemistry, are PhD student Jimin Zheng and post-doctoral fellow Vinay Singh; and Microbiology & Immunology Masters student Chunhua He.

The group is studying sensory pathways used by bacteria that enter our bodies and move from the stomach into the gastro-intestinal tract. If we can block the sensory pathway, then the bacteria cant adapt to that change in their environment, and wont be able to infect, says Dr. Martin.

In North America, the people treated for food poisoning with drugs tend to be elderly or immune compromised where there is a need for antibiotics to clear the infection. Since the organism that causes salmonellosis is correlation to that responsible for typhoid fever a huge problem in less developed countries the model being developed at Queens could potentially be a target for treating typhoid as well. The underlying goal is to control, if not clear, the infection.

Its basic science that we are doing, but were using that as a foundation for trying to develop approaches that will have positive impacts on human health, says Dr. Martin.


Posted by: Mark    Source