MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: Continuous oral contraceptives better at easing pain, bleeding

Back to obgyn news Blogs list Cancer blog  


Subscribe To Obgyn News RSS Feed  RSS content feed What is RSS feed?

Continuous oral contraceptives better at easing pain, bleeding




Continuous oral contraceptives may be more effective than the standard 28-day birth control pills in suppressing the ovary, as per researchers. They say that the continuous pill also causes a significant improvement in pain and behavioral changes.

"We have provided a biological proof of concept that both the ovary and the lining of the uterus are suppressed better and quicker with the continuous pill than with the cyclic pill. And there is no harmful effect on the lining of the uterus either," said Richard Legro, M.D., professor of obstetrics and gynecology, Penn State College of Medicine and lead author of the study.



Continuous oral contraceptives better at easing pain, bleeding

Standard 28-day birth control pills mimic a woman's natural menstrual cycle, while preventing pregnancy. A standard dose includes 21 hormone pills to suppress growth in the endometrium, the lining of the uterus, and seven placeholder placebo pills.

Continuous oral contraceptives may be more effective in treating several medical conditions, where continuous ovarian suppression is desired, such as acne, hirsutism, premenstrual syndrome, endometriosis and polycystic ovary syndrome. But there have been few detailed studies of ovarian function on the pill to demonstrate this effect.

Legro and colleagues compared the effectiveness of continuous oral contraceptives with that of the cyclical pills. The scientists monitored 62 healthy women, randomly assigned to receive either cyclical or continuous birth control pills, for six months with both scientists and participants blinded to the study group.

"We monitored vaginal bleeding, quality of life, and ovarian and endometrial suppression," said Legro, whose team's findings appeared in a recent issue of the Journal of Clinical Endocrinology and Metabolism.

The scientists found a significant decrease in moderate to heavy bleeding days among women who received the continuous birth control regimen. Women in the continuous group also had a significant decline in circulating and urinary estrogen levels, total ovarian volume and lead follicle size all biomarkers that indicate the ovary is less active and reported less pain and behavioral changes in comparison to women in the cyclic group.

However, results from the study also indicate greater breakthrough bleeding, or spotting, among women in the continuous group.

Legro says that while greater breakthrough bleeding may be a truly objectionable side effect for a number of women, it does not seem to affect their quality of life.

"That is one of the unique things of this study. The quality of life did not necessarily decrease as it was counterbalanced by improvements in other areas such as pain and mood swings," the Penn State researcher added.

As per Legro, the study suggests that there may be diverse mechanisms of breakthrough bleeding depending on whether a woman is using either a cyclical or continuous regimen of birth control pills.

In the case of cyclic pills, the ovary comes back into the equation during the pill free interval leading to a rebound increased secretion of ovarian hormones, which in turn contributes to some breakthrough bleeding, he explained.

"Breakthrough bleeding in the continuous group, in our opinion, is most likely due to the fact that the pill does too good of a job in suppressing the ovary and the lining of the uterus gets a little bit thin and fragile so that from time to time there is a little bit of bleeding," added Legro, whose work is funded by the National Institutes of Health.

The study provides a physical reason for continuous oral contraceptive pills to treat such chronic medical conditions such as polycystic ovary syndrome, endometriosis and premenstrual syndrome, where additional suppression of the ovary or the endometrium is desired, and Legro noted that other chronic conditions such as high blood pressure or diabetes are treated continuously, not three weeks out of four. Further studies showing a favorable risk benefit ratio of continuous oral contraceptives on these disorders are the next step.


Posted by: Emily    Source




Did you know?
Continuous oral contraceptives may be more effective than the standard 28-day birth control pills in suppressing the ovary, as per researchers. They say that the continuous pill also causes a significant improvement in pain and behavioral changes. "We have provided a biological proof of concept that both the ovary and the lining of the uterus are suppressed better and quicker with the continuous pill than with the cyclic pill. And there is no harmful effect on the lining of the uterus either," said Richard Legro, M.D., professor of obstetrics and gynecology, Penn State College of Medicine and lead author of the study.

Medicineworld.org: Continuous oral contraceptives better at easing pain, bleeding

Asthma| Hypertension| Medicine Main| Diab french| Diabetes drug info| DruginfoFrench| Type2 diabetes| Create a dust free bedroom| Allergy statistics| Cancer terms| History of cancer| Imaging techniques| Cancer Main| Bladder cancer news| Cervix cancer news| Colon cancer news| Esophageal cancer news| Gastric cancer news| Health news| Lung cancer news| Breast cancer news| Ovarian cancer news| Cancer news|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.