Antidepressant Drug May Help Depression In Diabetics

team of scientists at Washington University School of Medicine in St. Louis found that an antidepressant medicine may reduce the risk of recurrent depression and increase the length of time between depressive episodes in patients with diabetes.

"That's important not only because people with diabetes will feel better if we can control their depression. It's also key to helping manage blood sugar," says Patrick J. Lustman, Ph.D., principal investigator and professor of psychiatry. "As depression improves, glucose levels also tend to improve."

Eventhough depression affects about 5 percent of the general population, the rate is about 25 percent for patients with diabetes. Lustman's team previously demonstrated that therapy with antidepressant drugs and psychotherapy is an effective way to treat depression in patients with diabetes, but often depression would quickly redevelop.

"As we better understand depression, it's clear that for a number of patients, it is a chronic and recurring disease," Lustman says. "That appears to be particularly true for patients with diabetes compared to those otherwise free of medical illness".

Eventhough they knew that short-term therapy with antidepressants was helpful with mood and with control of blood glucose, Lustman's team didn't know whether the drug could prevent the recurrence of depression in patients with diabetes. He also didn't know what would happen to glucose levels in the months following successful depression treatment.

So Lustman teamed up with researchers at the University of Arizona, Tucson, and at the University of Washington, Seattle. They studied a total of 152 patients with diabetes at the three sites. The sample included patients with type 2 diabetes and patients with juvenile, or type 1, diabetes. Study participants averaged just over 50 years of age, and all had recovered from an episode of depression following therapy with sertraline (Zoloft®).

After their depression was under control, half of the study patients continued to take sertraline while the other half took an inactive placebo. Patients were followed for up to a year or until their depression recurred. During that time, researchers regularly measured blood glucose levels by keeping track of hemoglobin A1C, which reflects an individual's control of blood glucose over two to three months.

At one year, more than 65 percent of those still taking sertraline remained in remission from their depression. Only about 48 percent of those taking placebo were still in remission. On average, those who continued to take sertraline stayed free of depression four times longer than those who did not continue to take medication. Blood glucose levels remained lower in both groups of patients, as long as depression remained under control.

"That's very important," Lustman says. "We now know that controlling depression, by whatever method -- whether with exercise, activity, cognitive treatment or medicine -- improves the likelihood that blood glucose will be better controlled. That's the key to preventing the complications of diabetes, such as eye disease, neuropathy and kidney disease."



Posted by: JoAnn    Source