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Medicineworld.org: Fenretinide For Breast Cancer Prevention?

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Fenretinide For Breast Cancer Prevention?


Fenretinide For Breast Cancer Prevention?
A trial meant to reduce the risk of recurrence of breast cancer in postmenopausal women by taking a vitamin like drug had just the opposite effect. Instead of decreasing the risk of breast cancer the drug has actually increased the risk of breast cancer.

Postmenopausal women who took the vitamin A derivative called fenretinide daily for five years after breast cancer surgery to help prevent cancer recurrence ended up having 23 percent increase in the breast cancer incidence compared to women who were not taking this drug.

A subgroup of younger premneopausal women however experienced a 38 percent reduction in the breast cancer recurrence.

This result comes from re-analysis of data from a 15-year study, which included 2,800 women from Europe who had undergone surgery for breast cancer. These research results appeared in the recent issue of the Annals of Oncology.

When the initial results from this trial was published in 1999 with data from the initial 11 years of the study, experts believed that the data showed no support for the argument that this drug decreases risk of breast cancer. Fenretinide is not approved for breast cancer prevention in the United States. Users of the drug have also experience higher incidence of night blindness in some users.

Encouraging results for younger breast cancer patients provides room for further clinical trials in this issue focusing on younger breast cancer patients. However it is to be noted that women in this study did not receive tamoxifen or chemotherapy after breast cancer surgery hence the findings of the study can't be extended to the breast cancer population of the United States.

Posted by Sherin




Did you know?
A trial meant to reduce the risk of recurrence of breast cancer in postmenopausal women by taking a vitamin like drug had just the opposite effect. Instead of decreasing the risk of breast cancer the drug has actually increased the risk of breast cancer. Postmenopausal women who took the vitamin A derivative called fenretinide daily for five years after breast cancer surgery to help prevent cancer recurrence ended up having 23 percent increase in the breast cancer incidence compared to women who were not taking this drug.

Medicineworld.org: Fenretinide For Breast Cancer Prevention?

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