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House dust may protect against allergic disease

House dust may protect against allergic disease
Endotoxin, a toxic substance made by certain types of bacteria, may reduce the risk of developing the allergic skin condition eczema or wheezing in children if they are exposed to it up to age 3, suggests a study presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.

Endotoxin is a part of the cell wall of gram-negative bacteria, a type of bacteria that often causes disease. Endotoxin is released when the bacteria dies or is damaged. The new study observed that the lower the amount of endotoxin in young childrens homes, the more likely they were to have wheezing or eczema by age 3. The higher the amount of endotoxin in their homes, the less likely they were to develop either condition by age 3.

Were trying to find why children exposed to endoxotin have lower levels of disease early in life, says researcher Melisa Celaya, M.A., of the Arizona Respiratory Center in Tucson.

Celaya observed that certain environmental factors increased the levels of endotoxin in a home: having a home older than 30 years, substandard home conditions, carpeting, a musty smell and interior wall leaks were all linked to higher levels of endotoxin.

Blood samples were taken from 484 children enrolled in the Infant Immune Study at different ages, up to 5 years of age. We will be looking at the relationship between endotoxin levels in the home and chemicals (called cytokines) that are produced by certain immune system cells, to see why children exposed to lower levels are in the process of developing more allergic symptoms later on, she says. This study is unusual in that we are following children over a long period, and are looking at both environmental factors and immunological factors, so we can correlate the two.

The scientists also plan to study whether genetic predisposition changes a childs responses to environmental triggers.


Posted by: JoAnn    Source




Did you know?
Endotoxin, a toxic substance made by certain types of bacteria, may reduce the risk of developing the allergic skin condition eczema or wheezing in children if they are exposed to it up to age 3, suggests a study presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.

Medicineworld.org: House dust may protect against allergic disease

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