Cauliflower juice fights breast cancer
Eat cauliflower regularly, that's the advice for women who want to decrease the risk of breast cancer. Eating cauliflower daily could provide the body with powerful tools to help fight breast cancer, as per a new Italian study.
Cauliflower belongs to Brassicaceae mustard/cabbage family that includes brussels sprouts and broccoli, and a raft of studies have already suggested these vegetables could be an important source of health benefiting compounds. Scientists at the University of Urbino have discovered the mechanism of action by which Brassica oleracea (cauliflower) may offer protection against breast cancer.
"Cell growth inhibition was accompanied by significant cell death at the higher juice concentrations," they report in the June issue of The Journal of Nutrition.
The investigators stressed that they found all cauliflower varieties tested suppressed cell proliferation in a dose-dependent manner.
The investigators also found that the cauliflower compounds had a particular preference for targeting breast cancer cells, compared with other mammalian cell lines investigated.
These findings build on mounting evidence that suggests compounds found in fruit and vegetables, notably green leafy vegetables, could help the body fight a raft of diseases.
For the latest Italian study researchers investigated the anti-proliferate activity of juice obtained from leaves of several varieties of Brassica oleracea on both estrogen receptor (ER)-positive and ER-negative human breast cancer cell lines.
The effect of juice on cell proliferation was evaluated on DNA synthesis and on cell cycle–related proteins.
Juice markedly reduced DNA synthesis, starting from low concentrations (final concentration 5–15 mL/L), and this activity was independent of ER.
All cauliflower varieties tested suppressed cell proliferation in a dose-dependent manner. Cell growth inhibition was accompanied by significant cell death at the higher juice concentrations, although no evidence of apoptosis (programmed cell death) was found, write the scientists.
These results suggest that the edible part of Brassica oleracea contains substances that can markedly inhibit the growth of both ER+ and ER– human breast cancer cells, although through different mechanisms.
"These results suggest that the widely available cruciferous vegetables are potential chemo-preventive agents,“ conclude the researchers.