MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: New Test Identifies Patients Who Benefit From Targeted Cancer Drugs

Back to cancer blog Blogs list Cancer blog  


Subscribe To Cancer Blog RSS Feed  RSS content feed What is RSS feed?

New Test Identifies Patients Who Benefit From Targeted Cancer Drugs

New Test Identifies Patients Who Benefit From Targeted Cancer Drugs
The Weisenthal Cancer Group today announced that clinical data published at the annual meeting of the American Society of Clinical Oncology (ASCO) show that a new laboratory test it has developed accurately identified patients who would benefit from therapy with the molecularly-targeted anti-cancer therapies gefitinib (Iressa, AstraZeneca) and erlotinib (Tarceva®, Genentech). The new test, called the EGFRx- assay, predicted accurately for the survival of patients treated with the targeted drugs. The finding is important because the EGFRx- test, which can also be applied to a number of emerging targeted cancer drugs, could help to help to solve the growing problem of knowing which patients should receive costly, new therapys that can have harmful side-effects and which work for some but not all cancer patients who receive them.

Larry Weisenthal, M.D., Ph.D., a medical oncologist and developer of the EGFRx assay explains that the new test relies upon what he calls "Whole Cell Profiling" in which living tumor cells are removed from an individual cancer patient and exposed in the laboratory to the new drugs. A variety of metabolic and apoptotic measurements are then used to determine if a specific drug was successful at killing the patient's cancer cells. The whole cell profiling method differs from other tests in that it assesses the activity of a drug upon combined effect of all cellular processes, using several metabolic and morphologic endpoints. Other tests, such as those which identify DNA or RNA sequences or expression of individual proteins often examine only one component of a much larger, interactive process.

As per Dr. Weisenthal, this may explain why EGFRx whole cell profiling is the only test to date to demonstrate a statistically significant association between prospectively reported test results and patient survival. Using the EGFRx assay and the whole cell profiling method, Dr. Weisenthal's group correlated test results, which were obtained by his lab and reported to physicians previous to patient therapy, with significantly longer or shorter overall patient survival depending upon whether the drug was found to be effective or ineffective at killing the patient's tumor cells in the laboratory. Patients prospectively identified by Dr. Weisenthal as favorable candidates averaged 485 days of life after therapy with the targeted treatment drugs. In contrast, patients identified as unfavorable candidates for the drugs averaged 75 days survival after receiving the drugs. This compares to 76 days average survival among patients identified as unfavorable candidates and who did not receive a targeted treatment drug. Survival among patients identified by Dr. Weisenthal as unfavorable candidates was therefore similar regardless nof whether or not they received the targeted drugs.

Comparing the whole cell profiling approach with other types of tests Dr. Weisenthal states, "Over the past few years, scientists have put enormous efforts into genetic profiling as a way of predicting patient response to targeted therapies. However, no gene-based test as been described that can discriminate differing levels of anti-tumor activity occurring among different targeted treatment drugs. Nor can an available gene-based test identify situations in which it is advantageous to combine a targeted drug with other types of cancer drugs. So far, only whole profiling has demonstrated this critical ability. The reason this is critical is because there is a growing array targeted drugs to choose from. Also, most patients today are treated not with a targeted treatment drug alone but rather with a combination of chemotherapy drugs. Therefore, then existing DNA and RNA tests do not reflect the way cancer medicine actually is practiced today".

Several new targeted drugs have been introduced during the last few years and dozens more are on the horizon. These so-called "smart drugs" focus their effects on specific, identifiable processes occurring within cancer cells. The new drugs are highly promising in that they sometimes provide benefit to patients who have failed traditional therapies. However, they do not work for everyone, they often have unwanted side effects, and they are all extremely expensive: some cost patients and insurance carriers $5,000 to $7,000 or more per month of therapy. Patients, physicians, insurance carriers, and the FDA are all calling for the discovery of predictive tests that allow for rational and cost-effective use of these drugs.

Dr. Weisenthal believes that his cell profiling approach, which he already provides routinely for many physicians nationwide, holds the key to solving some of the problems confronting a healthcare system that is seeking ways to best allocate available resources while accomplishing the critical task of matching individual patients with the therapys most likely to benefit them.

"Not only is this an important predictive test that is available today", says Dr. Weisenthal, "but it is also a unique tool that can help to identify newer and better drugs, evaluate promising drug combinations, and serve as a 'gold standard' correlative model with which to develop new DNA, RNA, and protein-based tests that better predict for drug activity".



Posted by: Janet    Source




Did you know?
The Weisenthal Cancer Group today announced that clinical data published at the annual meeting of the American Society of Clinical Oncology (ASCO) show that a new laboratory test it has developed accurately identified patients who would benefit from therapy with the molecularly-targeted anti-cancer therapies gefitinib (Iressa, AstraZeneca) and erlotinib (Tarcevaandreg;, Genentech). The new test, called the EGFRx- assay, predicted accurately for the survival of patients treated with the targeted drugs. The finding is important because the EGFRx- test, which can also be applied to a number of emerging targeted cancer drugs, could help to help to solve the growing problem of knowing which patients should receive costly, new therapys that can have harmful side-effects and which work for some but not all cancer patients who receive them.

Medicineworld.org: New Test Identifies Patients Who Benefit From Targeted Cancer Drugs

Main Page| Cancer blog| Cancer blogs list| Lung cancer blog| Colon cancer blog| Prostate cancer blog| Breast cancer blog| Diabetes watch blog| Heart watch blog| Allergy blog| Bladder cancer blog| Cervical cancer blog| Colon cancer news blog| Diabetes news blog| Esophageal cancer blog| Gastric cancer blog| Health news blog| Heart news blog| Infectious disease blog| Kidney watch blog| Lung disease blog| Lung cancer news blog| Mesothelioma blog| Neurology blog| Breast cancer news blog| OBGYN blog| Ophthalmology blog| Ovarian cancer blog| Cancer news blog| Pancreas cancer blog| Pediatrics blog| Prostate cancer news blog| Psychology blog| Research blog| Rheumatology blog| Society news blog| Uterine cancer blog| Weight watch blog|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.