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Medicineworld.org: Cancer-fighting virus shows promise

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Cancer-fighting virus shows promise




A virus that has been specifically designed by researchers to be safe to normal tissue but deadly to cancer is showing early promise in a preliminary study, scientists said today at the ESMO Conference Lugano (ECLU), Switzerland.

The virus, called NV1020, is a type of herpes simplex virus modified so that it selectively replicates in virus cells, killing them in the process.



Cancer-fighting virus shows promise

It doesnt replicate in normal, healthy cells, so our hope is that it will help fight cancers without causing side-effects in the rest of the body, said Dr. Axel Mescheder, VP Clinical Research & Development, from the Munich-based biotech company MediGene. The study is conducted in seven leading US-cancer centers, with Dr. Tony Reid from the University of California in San Diego, CA as Principal Investigator. Dr. Mescheder presented preliminary safety and efficacy results and a case report from this ongoing clinical trial in patients with colorectal cancer metastatic to the liver at the meeting.

Dr. Mescheders poster presentation described the case of a patient whose cancer had spread to 10 different places around the liver and four in the lungs. He was given the virus therapy in four weekly infusions direct into blood stream, followed by two cycles of approved chemotherapy.

Six months after therapy, scans showed the liver masses had nearly disappeared. The reduction in the tumor masses was really impressive in this patient, Dr. Mescheder said. The hepatic masses almost disappeared.

The patient survived for 12 months after therapy.

In the current study, the researchers are testing the therapy in patients with colorectal cancer that have not responded to chemotherapy and where the cancer has spread to the liver, Dr. Mescheder said. We are hoping to extend overall survival.

So far, the findings are looking positive. The therapy seems very tolerable for patients and safe. The results are really quite encouraging at this early stage, he said.

Almost 40% of patients with colorectal cancer ultimately die from metastatic disease, where the cancer spreads to other parts of the body. Most of the spreading occurs to the liver and 15% of patients have liver metastases at the time of diagnosis.

The latest human results reported today follow testing in the lab and in animals where the virus was shown to be effective at killing colorectal cancer cells and liver cancers.


Posted by: Janet    Source




Did you know?
A virus that has been specifically designed by researchers to be safe to normal tissue but deadly to cancer is showing early promise in a preliminary study, scientists said today at the ESMO Conference Lugano (ECLU), Switzerland. The virus, called NV1020, is a type of herpes simplex virus modified so that it selectively replicates in virus cells, killing them in the process.

Medicineworld.org: Cancer-fighting virus shows promise

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