MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: New joint replacement material

Back to society news Blogs list Cancer blog  


Subscribe To Society News RSS Feed  RSS content feed What is RSS feed?

New joint replacement material




New joint replacement material
Image courtesy of hughston.com
Massachusetts General Hospital (MGH) surgeons have performed the first total hip replacement using a joint socket lined with a novel material invented at the MGH. An advance over first-generation highly crosslinked polyethylene, which was also developed at MGH and significantly reduced a serious complication of early hip implants, the new material may be applied in replacements for a wider variety of joints in a more diverse group of patients.

We think this material could be used for any joint in the body and in any implant design, even those demanding higher flexion and more mobility, says Orhun Muratoglu, PhD, co-director of the Harris Orthopdics Biomechanics and Biomaterials Laboratory (OBBL) at MGH, who developed the new material in collaboration with researchers at the Cambridge Polymer Group.

Total replacements for hips and other joints were developed in the late 1960s, but it soon became apparent that hip implants could start loosening about 5 years after surgery and would eventually fail completely. A team led by William Harris, MD, DSc, now director emeritus of the MGH OBBL, investigated this complication and observed that long-term friction of the implants head against the polyethylene-lined joint socket would break off small particles of polyethylene. The bodys immune system reacted against these foreign particles, eventually destroying adjacent bone tissue and causing the implant to loosen a condition called periprosthetic osteolysis.

Harris and colleagues, working with polymer chemists from MIT, observed that high doses of radiation would crosslink the polyethylene, bonding molecules together to produce a much more durable material. The procedure also generates free radicals that could lead to oxidization and degradation of the implant, but the research team observed that melting the material would eliminate free radicals. The first-generation highly crosslinked polyethylene was approved by the FDA for use in implants in 1999 and has been licensed to Zimmer, Inc.

However, the MGH scientists knew that the first-generation material had limitations in strength that made it unsuitable for some types of joint replacement implants. Subsequently, Muratoglu observed that oxidation could be blocked by diffusing the antioxidant vitamin E throughout the polyethylene material. Both mechanical testing and animal studies have shown that the new material resists wear as well as the first generation and is much stronger. Vitamin-E-stabilized, highly crosslinked polyethylene has also received FDA approval for use in joint implants and has been licensed to both Zimmer and to Biomet, Inc., which made the implant used in the first surgical procedure on July 16.

This material will allow us to offer our patients very long-term, high-performance joint replacements, says Andrew A. Freiberg, MD, chief of the Arthoplasty Service in the MGH Department of Orthopdics, who performed the first implant with the new material. It should be suitable for higher-stress applications in younger patients, those who are more active and those who are heavier.


Posted by: Janet    Source




Did you know?
Massachusetts General Hospital (MGH) surgeons have performed the first total hip replacement using a joint socket lined with a novel material invented at the MGH. An advance over first-generation highly crosslinked polyethylene, which was also developed at MGH and significantly reduced a serious complication of early hip implants, the new material may be applied in replacements for a wider variety of joints in a more diverse group of patients.

Medicineworld.org: New joint replacement material

Asthma| Hypertension| Medicine Main| Diab french| Diabetes drug info| DruginfoFrench| Type2 diabetes| Create a dust free bedroom| Allergy statistics| Cancer terms| History of cancer| Imaging techniques| Cancer Main| Bladder cancer news| Cervix cancer news| Colon cancer news| Esophageal cancer news| Gastric cancer news| Health news| Lung cancer news| Breast cancer news| Ovarian cancer news| Cancer news|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.