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Medicineworld.org: Improving memory in Alzheimer's disease mice

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Improving memory in Alzheimer's disease mice




Overactivation of proteins known as calpains, which are involved in memory formation, has been associated with Alzheimer disease. Ottavio Arancio and his colleagues, at Columbia University, New York, have now shown that two different drugs that inhibit calpains can improve memory in a mouse model of Alzheimer disease (APP/PS1 mice), leading them to suggest drugs that target calpains might stop or slow down the memory loss that occurs as Alzheimer disease progresses.



Improving memory in Alzheimer's disease mice

It is thought that dysfunctional signaling between nerve cells contributes to the impaired cognition experienced by individuals with Alzheimer disease. In the study, analysis of cells and tissue slices from APP/PS1 mice, specifically cells from the part of the brain known as the hippocampus and hippocampal slices, indicated that exposure to calpain inhibitors restored signaling between nerve cells to normal. The authors therefore suggest that calpain inhibitors improve memory in APP/PS1 mice because they reestablish normal signaling between nerve cells.


Posted by: Daniel    Source




Did you know?
Overactivation of proteins known as calpains, which are involved in memory formation, has been associated with Alzheimer disease. Ottavio Arancio and his colleagues, at Columbia University, New York, have now shown that two different drugs that inhibit calpains can improve memory in a mouse model of Alzheimer disease (APP/PS1 mice), leading them to suggest drugs that target calpains might stop or slow down the memory loss that occurs as Alzheimer disease progresses.

Medicineworld.org: Improving memory in Alzheimer's disease mice

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