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Medicineworld.org: New Alzheimer's predictors

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New Alzheimer's predictors




By combining MRI brain scans and measurements of certain compounds in the cerebrospinal fluid, NYU scientists were able to distinguish individuals who would develop Alzheimer's disease over a two-year period. In a study of 23 people, they found atrophy in areas of the brain involved in learning and memory, and significantly higher CSF levels of phosphorylated tau and other compounds among individuals who would develop Alzheimer's in comparison to those individuals who didn't progress from mild cognitive impairment over the two-year period. This preliminary study suggests that combining these tests could help predict which individuals with mild cognitive impairment are at the highest risk for developing Alzheimer's disease.

Presentation # P3-067.



New Alzheimer's predictors

Big Immune Response to Common Mouth Bacteria Associated with Alzheimer's.
Angela R Kamer, D.M.D., M.S., PhD., Assistant Professor, College of Dentistry, New York University.

In a study investigating the link between Alzheimer's disease and a heightened inflammatory-immune response, NYU scientists observed that twice as a number of subjects with probable Alzheimer's disease tested positive for antibodies in their plasma against a type of bacteria that is usually found in the mouth. The pioneering study supports a growing body of evidence that associates notable immune changes with a means of predicting and classifying Alzheimer's disease. Together with other immune markers linked to Alzheimer's disease, antibodies to these periodontal bacteria could serve to better understand the causes and mechanisms of the disease, the scientists say.

Presentation # P1-348.

Signs of Brain Disease among Healthy Individuals
Lidia Glodzik, MD, PhD, Research Physician, Center for Brain Health at NYU Langone Medical Center.



NYU scientists identified signs of pathology before the clinically noticeable stages of mild cognitive impairment that normally precede Alzheimer's disease. The study involved a cognitively normal group of people ages 40 to 86. It observed that higher levels of tau protein in the cerebrospinal fluid correlated with lower grey matter density in brain regions that are important for learning and memory, and are susceptible to Alzheimer's. Combining cerebrospinal fluid measurements and imaging markers to identify normal subjects who are more vulnerable to the neurodegenerative disease opens an opportunity to explore early detection in the service of prevention, the scientists report.

Presentation # PS-070.

Couples Counseling Helps the Spouse Caregiver
Mary S. Mittelman, Dr.P.H., Research Professor in the Department of Psychiatry at New York University School of Medicine.


When the patient with Alzheimer's and their spouse caregiver are counseled separately, they are expected to go home and live together. Can couples counseling help stabilize their relationship as they grapple with the disease? Early results show that it can. In a pilot study, scientists at NYU's Silberstein Center offered six counseling sessions focused on the new needs of each member of a couple brought about by the illness. Each of the ill spouses was in the early stages of dementia and could still participate in a counseling session. The NYU scientists report that all caregivers were surprised by how much the person with dementia could communicate in the session. They also report that relationships improved as a result of the counseling, and the caregivers became less depressed.

Presentation # P4-429.

Subjective Memory Complaints a Predictor of Further Cognitive Decline
Barry Reisberg, MD, Professor, Department of Psychiatry at NYU Langone Medical Center.


An NYU study that followed 213 healthy adults over an average of 7 years observed that subjects with subjective memory complaints at the first evaluation were almost 7 times more likely to experience cognitive decline to mild cognitive impairment or dementia in comparison to adults without initial complaints. This is the first prediction study to link subjective cognitive impairment to both mild cognitive impairment and dementia and underlines the importance in studying early, non-specific symptoms that arise before mild cognitive impairment is apparent, the scientists report. Such efforts are critical to preventing the disease. To develop preventive interventions it may be necessary to accurately identify the disease in its earliest manifestations, when symptoms are first emerging, say the NYU researchers. These subjective symptoms appear to occur as early as twenty or more years before the overt dementia of Alzheimer's appears.

Presentation # PS-043.

A Decreasing Ability to Learn Among Aging Healthy Carriers of APOE 4
Nunzio Pomara, M.D., Professor in the Department of Psychiatry, NYU Langone Medical Center; Director of the Geriatric Psychiatry Program, Nathan S. Kline Institute.




Posted by: Daniel    Source




Did you know?
By combining MRI brain scans and measurements of certain compounds in the cerebrospinal fluid, NYU scientists were able to distinguish individuals who would develop Alzheimer's disease over a two-year period. In a study of 23 people, they found atrophy in areas of the brain involved in learning and memory, and significantly higher CSF levels of phosphorylated tau and other compounds among individuals who would develop Alzheimer's in comparison to those individuals who didn't progress from mild cognitive impairment over the two-year period. This preliminary study suggests that combining these tests could help predict which individuals with mild cognitive impairment are at the highest risk for developing Alzheimer's disease.

Medicineworld.org: New Alzheimer's predictors

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