MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Medicineworld.org: Young women's breast cancers have more aggressive genes

Back to breast cancer blog Blogs list Cancer blog  


Subscribe To Breast Cancer Blog RSS Feed  RSS content feed What is RSS feed?

Young women's breast cancers have more aggressive genes




Young women's breast cancers tend to be more aggressive and less responsive to therapy than the cancers that arise in older women, and scientists at the Duke Comprehensive Cancer Center and the Duke Institute for Genome Sciences & Policy may have discovered part of the reason why: young women's breast cancers share unique genomic traits that the cancers in older women do not exhibit.



Young women's breast cancers have more aggressive genes

"Clinicians have long noted that the breast cancers we see in women under the age of 45 tend to respond less well to therapy and have higher recurrence rates than the disease we see in older women, especially those over the age of 65," said Kimberly Blackwell, M.D., a breast oncologist at Duke and senior investigator on the study. "Now we're really understanding why this is the case, and by understanding this, we may be able to develop better and more targeted therapies to treat these younger women".

The results appear in the July 10 Journal of Clinical Oncology The study was funded by the National Cancer Institute.

Duke scientists looked at samples of nearly 800 breast tumors from women in five countries on three continents, and divided them into age-specific cohorts. The researchers found more than 350 sets of genes that were active only in the tumors from women under age 45. On the other hand, tumors arising in women over age 65 did not share these activated gene sets.

"The breast tumors that arose in younger women shared a common biology, and this discovery was truly remarkable," Blackwell said. "The genes that regulate things like immune function, oxygen supply and mutations that we know are correlation to breast cancer, such as BRCA1, were preferentially expressed in the tumors taken from younger women, but when we compared younger women's tumors to older women's tumors, we found those same gene sets were not expressed in the 'older' tumors".

Scientists have already developed compounds that target some of the activated gene expression pathways that the Duke team discovered, and a number of of these compounds have promise for combating young women's tumors, Blackwell said. Identifying these characteristic gene expression profiles will be an important part of finding new therapies, she said.

"A number of of the gene sets we saw in 'younger' tumors distinguished these cancers from 'older' tumors but the reverse was not true -- there was nothing we saw in the older women's tumors that set them apart genomically," Blackwell said. "Identifying these distinguishing characteristics may be the first step in developing more effective therapys for these younger patients".


Posted by: Janet    Source




Did you know?
Young women's breast cancers tend to be more aggressive and less responsive to therapy than the cancers that arise in older women, and scientists at the Duke Comprehensive Cancer Center and the Duke Institute for Genome Sciences and Policy may have discovered part of the reason why: young women's breast cancers share unique genomic traits that the cancers in older women do not exhibit.

Medicineworld.org: Young women's breast cancers have more aggressive genes

BREAST CANCER MAIN| Home| Breast cancer news| Common terms| Breast cancer treatment| Breast cancer treatment by stage| Mammogram and breast cancer screening| Surgical treatment of breast cancer| Chemotherapy of breast cancer| Chemo drugs used in breast cancer| Doxorubicin| Cyclophosphamide| Methotrexate| Hormonal therapy of breast cancer| Radiation therapy of breast cancer| Monoclonal therapy| High dose chemotherapy for breast cancer| Recurrent breast cancer| Bisphosphonates and breast cancer| Pregnancy and breast cancer| Risk factors for breast cancer| Risk details| My risk| Comprehensive breast cancer information| Breast cancer statistics| African Americans and breast cancer| Ashkenazi and breast cancer| Asians| Hispanic| Men| Native Americans| Older women and breast cancer| Younger women| Pregnant women and breast cancer| BRCA|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.