MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

From Medicineworld.org: Enzymes That Regulate Spread of Breast Cancer discovered

Breast cancer treatment Breast cancer main Breast cancer news  

Enzymes That Regulate Spread of Breast Cancer discovered


Researchers from Virginia Commonwealth University Massey Cancer Center have discovered a new signaling component that controls the spread of breast cancer cells. The movement of breast cancer cells of human beings is influenced towards epidermal growth factor by this component.

Research data published in the recent issue of issue of the Journal of Biological Chemistry shows that the enzymes sphingosine kinases - SphK1 and SphK2 is stimulated by epidermal growth factor. The progression of breast cancer may depend on epidermal growth factor. The potent lipid mediator, sphingosine-1-phosphate is formed by the enzyme family sphingosine kinases - SphK1 and SphK2. The movement of the breast cancer cells without these kinases is not possible.

The opinion of the leading author Sarah Spiegel is that better tools could be designed for the treatment of cancers if the spreading of tumor cells or metastasize is understood properly. The Massey Cancer Center Cell Signaling program has Sarah Spiegel, Ph.D., as its co-leader who is also the professor in the VCU Department of Biochemistry.

The role of sphingosine-1-phosphate in the regulation of cell growth was first discovered by Spiegel and her colleagues about a decade back. She is the pioneer to work on new lipid mediators which is supposed to regulate cell growth and cell death. She is recognized internationally for this work.
Although the fact that multiple growth factors stimulates SphK1 is known to researchers, the regulation of SphK2 is not very clear. However, for understanding the functions of these enzymes in a better way, this work is being continued by Spiegel and her team.
Spiegel said that in cancer therapy the potential new targets are sphingosine kinases. Grants from the National Cancer Institute has supported this research.


Did you know?
Researchers from Virginia Commonwealth University Massey Cancer Center have discovered a new signaling component that controls the spread of breast cancer cells. The movement of breast cancer cells of human beings is influenced towards epidermal growth factor by this component.

Medicineworld.org: Enzymes That Regulate Spread of Breast Cancer discovered

BREAST CANCER MAIN| Home| Breast cancer news| Common terms| Breast cancer symptoms| Mammogram and breast cancer screening| Treatment by stage| Surgical treatment| Chemotherapy| Chemo drugs| Doxorubicin| Cyclophosphamide| Methotrexate| Hormonal therapy| Radiation therapy| Monoclonal therapy| High dose chemotherapy| Recurrent breast cancer| Bisphosphonates| Pregnancy and breast cancer| Risk factors| Risk details| My risk| Comprehensive| Breast cancer statistics| African Americans| Ashkenazi| Asians| Hispanic| Men| Native Americans| Older women| Younger women| Pregnant women| BRCA|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.