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Medicineworld.org: Higher Blood Pressure Associated with Decline in Walking Ability

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Higher Blood Pressure Associated With Decline In Walking Ability

Higher Blood Pressure Associated with Decline in Walking Ability
Decline in lower limb function is common in older people, and worsening gait is linked to increased risk of dementia and death. However, factors contributing to gait difficulties in older persons are not well understood. A study by scientists at Rush University Medical Center suggests that higher blood pressure may be one factor linked to a decline in walking ability in later life. The research, by Dr. Raj Shah and his colleagues at the Rush Alzheimer's Disease Center, is reported in the August 2006 issue of the Journal of Gerontology: Medical Sciences, the scientific journal of The Gerontological Society of America.

Scientists recruited 888 older Catholic clergy without dementia or Parkinson's disease who are participating in the Religious Orders Study. At baseline, blood pressure was measured, the presence of vascular diseases and diabetes was recorded, cognitive function was assessed, and medications were inspected.

At baseline and subsequent annual visits, gait and balance were assessed using performance-based tasks, such as the time and number of steps taken to walk 8 feet, the time to sit up and down five times, the number of steps off the line during an 8-foot heel-to-toe walk, and a comparison of ability to stand with eyes open and eyes closed.

Participants completed a mean of nearly eight annual evaluations with a high rate of follow-up. Controlling for age, education, and gender, the study found a 10mmHg increment in systolic blood pressure was linked to greater decline in lower limb function. On average, lower limb function declined 28.7% faster in persons with a systolic blood pressure of 160 mmHg than in persons with a normal systolic blood pressure of 120 mmHg.

"After memory loss, the biggest concern of older individuals is loss of mobility," said Dr. Raj Shah, medical director of the Rush Alzheimer's Disease Center's Memory Clinic. "If hypertension is impacting gait, it is a risk factor that possibly can be controlled in order to help people stay active as they age".

The study wasn't able to determine why blood pressure is impacting gait. However, Shah notes it may partially be correlation to stroke. The study observed that diabetes, vascular diseases, or cognition did not change the association of blood pressure and lower limb function. Eventhough baseline clinical stroke had no effect on higher blood pressure being linked to lower limb function, when scientists took out individuals that developed stroke during the study, the relationship between blood pressure and mobility wasn't as strong.

Further studies examining lifelong blood pressure measures will be necessary to fully explore why there is a link between blood pressure and lower limb function. In addition, Shah hopes clinical trials will study if the therapy of blood pressure improves walking abilities.

"Gait difficulties are very common in elderly adults. We hope our research will lead to better therapy options and to preventive measures that will help elderly adults maintain active, independent lives," said Shah.

The researchers are part of the institution's Rush Alzheimer's Disease Center, headed by Dr. David Bennett. The AD Center is one of 30 across the U.S. supported by the National Institute on Aging (NIA) at the National Institutes of Health to study and care for Alzheimer's patients.

The Rush scientists are extremely grateful for the remarkable dedication and altruism of the volunteers participating in the Religious Orders Study, a longitudinal, clinical-pathologic study of older persons without dementia The research was supported by grants from the National Institute on Aging, which leads the Federal effort to support and conduct basic, clinical, and social and behavioral studies on aging and on Alzheimer's disease.



Posted by: Daniel    Source




Did you know?
Decline in lower limb function is common in older people, and worsening gait is linked to increased risk of dementia and death. However, factors contributing to gait difficulties in older persons are not well understood. A study by scientists at Rush University Medical Center suggests that higher blood pressure may be one factor linked to a decline in walking ability in later life. The research, by Dr. Raj Shah and his colleagues at the Rush Alzheimer's Disease Center, is reported in the August 2006 issue of the Journal of Gerontology: Medical Sciences, the scientific journal of The Gerontological Society of America.

Medicineworld.org: Higher Blood Pressure Associated with Decline in Walking Ability

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