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Medicineworld.org: After MS patients stop drug

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After MS patients stop drug




People with multiple sclerosis who stop taking the drug natalizumab may experience a rebound increase in disease activity, as per a research studypublished September 12, 2007, in the online edition of Neurology, the medical journal of the American Academy of Neurology.

The study involved 21 people who had MRI scans of their brains taken before taking natalizumab and again an average of 15 months after receiving the last infusion of the drug. The drug is given by IV infusion once a month. The participants were divided into two groups: one group took the drug for an average of three years, and the other group took the drug for an average of two months.



After MS patients stop drug

The participants developed more than three times as a number of brain lesions, or areas of damage in the brain that are a marker of MS disease activity, in the 15-month period after discontinuing the drug than they had developed before they started taking the drug. The results were most pronounced for those who took the drug for only a short time; they developed five times as a number of brain lesions after stopping the drug than they did before they started taking it.

More research needs to be done with larger numbers of patients before any recommendations can be made about use of the drug, as per study author Machteld Vellinga, MD, of VU University Medical Center in Amsterdam, the Netherlands. For now the recommendations remain the samepatients and their doctors should choose the most applicable therapy for them, she said.

Vellinga said its not clear why discontinuing the drug would lead to increased disease activity, eventhough an earlier animal study showed a similar result when rats with an animal model of multiple sclerosis were given a drug that suppresses the immune system.

The study came about because use of natalizumab was suspended in 2005 after three people participating in clinical trials for the drug developed a rare, often fatal brain disease called progressive multifocal leukoencephalopathy.

All of our patients had an MRI shortly after the drug was suspended, and our neuroradiologist noticed that in some patients a considerable number of new lesions developed on their MRIs in the following year, said Vellinga. We decided to do a formal analysis to see if this was actually the case. Vellinga noted that the results need to be confirmed in independent groups of patients.

The drug was reintroduced in 2006 with specific guidelines for its use and to monitor patients for signs of progressive multifocal leukoencephalopathy.


Posted by: Daniel    Source




Did you know?
People with multiple sclerosis who stop taking the drug natalizumab may experience a rebound increase in disease activity, as per a research studypublished September 12, 2007, in the online edition of Neurology, the medical journal of the American Academy of Neurology. The study involved 21 people who had MRI scans of their brains taken before taking natalizumab and again an average of 15 months after receiving the last infusion of the drug. The drug is given by IV infusion once a month. The participants were divided into two groups: one group took the drug for an average of three years, and the other group took the drug for an average of two months.

Medicineworld.org: After MS patients stop drug

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