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Medicineworld.org: Hundreds of genes controlling female fertility

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Hundreds of genes controlling female fertility




Scientists at UT Southwestern Medical Center have found nearly 350 genes correlation to female fertility. Their research may open the door to much wider study in the poorly understood field of infertility.

This study gives us a way to begin to understand the causes of female infertility, said Dr. Diego Castrillon, assistant professor of pathology and senior author of a study appearing in the recent issue of the journal Genetics It gives us a much more complete list of candidate genes to explore. Before, we didnt even know where to look.

The study was done in mice, but at the molecular level, ovarian biology is very similar in mice and humans, Dr. Castrillon said.



Hundreds of genes controlling female fertility

These discoveries might lead the way to eventually allowing clinicians to test whether an infertile woman has problems with a specific gene, allowing for improved diagnostic tests and tailored treatment in the future, said Dr. Castrillon, a specialist in the diagnosis of infertility and other diseases of women.

About 13 percent of women suffer from infertility, with the most common cause being dysfunction of the ovary. Scientists suspected genetic links in a number of cases, Dr. Castrillon said.

In mammals, the ovaries go through a developmental stage after birth in which egg cells become nestled in dormant nests called primordial follicles. Later in development, the follicles become activated by a process that scientists dont fully understand, and at puberty, egg cells begin being released for fertilization.

The scientists focused on a gene called Foxo3, which controls follicle activation. Normally, follicles are activated on a staggered schedule, so an ovary contains follicles at a number of different stages of development.

In female mice genetically engineered to lack Foxo3, the follicles are normal at birth, but later become activated all at the same time. This coordinated maturation meant that the genes controlling follicle growth were all turned on at the same time, making it easier to detect these genes.

The scientists employed a method known as expression profiling to identify the active genes. They found 348 genes that were active in ovaries in the mice lacking Foxo3, but not in other tissues, indicating that they could function specifically in follicle growth.

Some of the genes the scientists found were already known to be involved in infertility, which helped validate the experimental method. Most, however, were previously unknown, Dr. Castrillon said.

The scientists also randomly selected a small number of genes from the 348 and looked for them in human ovaries. Those specific genes proved to be active in early development of the human ovary.

Future work will focus on finding out how these genes communicate with each other to control follicle development, and study their contribution to female infertility, Dr. Castrillon said.


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Scientists at UT Southwestern Medical Center have found nearly 350 genes correlation to female fertility. Their research may open the door to much wider study in the poorly understood field of infertility. This study gives us a way to begin to understand the causes of female infertility, said Dr. Diego Castrillon, assistant professor of pathology and senior author of a study appearing in the recent issue of the journal Genetics It gives us a much more complete list of candidate genes to explore. Before, we didnt even know where to look.

Medicineworld.org: Hundreds of genes controlling female fertility

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