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Medicineworld.org: Radiation plus hormone therapy in prostate cancer

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Radiation plus hormone therapy in prostate cancer




Boston For men with locally advanced prostate cancer the addition of radiation therapy to anti-androgen hormone treatment reduces the risk of dying of prostate cancer by 50 percent in comparison to those who have anti-androgen hormone therapy alone, as per a randomized study presented September 22, 2008, at the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting in Boston.



Radiation plus hormone therapy in prostate cancer

"This randomized trial is the first to show that men with locally advanced prostate cancer will survive substantially longer when radiation is added to their therapy plan," Anders Widmark, M.D., lead author of the study and a professor in radiation oncology at Umea University in Umea, Sweden, said. "I would encourage men with locally advanced prostate cancer to talk to their doctor to see if they would be a good candidate for radiation treatment in addition to hormone therapy".

Locally advanced prostate cancer is cancer that has grown close to the border or outside the prostate gland and into neighboring tissue, but has not spread into the lymph nodes or to other organs. In this study, anti-androgen hormone treatment is used to treat prostate cancer by blocking the stimulating effect of testosterone on the prostate cancer cells, to shrink the prostate cancer and slow down the growth of prostate cancer. External beam radiation treatment (also called radiotherapy) involves a series of daily therapys to acurately deliver radiation to the prostate.

The study involved 880 patients with locally advanced prostate cancer who were randomly assigned to receive three months of intense hormone treatment (temporary castration) called total elimination of androgens in the body (total androgen blockade) followed by continuous anti-androgen treatment, allowing the testosterone to come back or the same hormonal therapy combined with radiation treatment between February 1996 to December 2002.

Findings show that 18 percent of patients who underwent hormone treatment alone died of prostate cancer, in comparison to nine percent of those who had both hormone and radiation therapy. The quality of life at four years after therapy was similar between the two groups, with the exception of decreased social function in the patients who had the combined therapy.


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Did you know?
Boston For men with locally advanced prostate cancer the addition of radiation therapy to anti-androgen hormone treatment reduces the risk of dying of prostate cancer by 50 percent in comparison to those who have anti-androgen hormone therapy alone, as per a randomized study presented September 22, 2008, at the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting in Boston.

Medicineworld.org: Radiation plus hormone therapy in prostate cancer

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