Avastin in combination with Chemotherapy Prolongs Survival in lung cancer
Avastin (bevacizumab ) in combination with chemotherapy has shown to increase survival as per the preliminary results from a large, randomized clinical trial for patients with previously untreated advanced non-small cell lung cancer. Patients who have squamous, non-small cell lung cancer were excluded from this study because of prior experience with bleeding in this group of patients with avastin. Patients who received bevacizumab (Avastin) in combination with standard chemotherapy lived longer than patients who received the same chemotherapy without bevacizumab.
This clinical trial was sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG). Bevacizumab (Avastin) is manufactured by Genentech, Inc.
Since the study had met its primary endpoint of improving overall survival, the Data Monitoring Committee overseeing the trial recommended that the results of a recent interim analysis be made public. The study showed that patients who received bevacizumab in combination with standard chemotherapy (consisting of paclitaxel and carboplatin) had a median overall survival of 12.5 months compared to patients treated with the standard chemotherapy alone, who had a median survival of 10.2 months. This difference was statistically significant. Details of the study will be presented in the forthcoming American Society of Clinical Oncology Annual Meeting (ASCO) to be held in Orlando, Fla., on May 13-17, 2005.
This is the first time a randomized study has shown an improvement in survival with the addition of a molecularly targeted agent to standard chemotherapy in this group of patients as per the Study Chair Alan B. Sandler, M.D., of the Vanderbilt University Medical Center in Nashville, Tenn.
This study demonstrates that mechanistic-based interventions such as angiogenesis inhibitors are making important contributions in improving cancer outcomes," said NCI Director Andrew C. von Eschenbach, M.D. "In combination with standard therapies, they can be used for a variety of cancers, leading to increased patient survival."
A total of 878 patients with advanced non-squamous, non-small cell lung cancer (NSCLC) who had not previously received systemic chemotherapy were enrolled in this study between July 2001 and April 2004. Patients were randomized to one of the two treatment arms. One patient group received standard treatment -- six cycles of paclitaxel and carboplatin. The second group received the same six-cycle chemotherapy regimen with the addition of bevacizumab, followed by bevacizumab alone until disease progression.
Patients with squamous cell carcinoma of the lung were not included in the study because previous clinical experience suggested that patients with this particular type of NSCLC had a higher risk of serious bleeding from the lung after bevacizumab therapy. Patients with a prior history of frank hemoptysis (coughing up blood) were also not enrolled on the trial.
The most significant adverse event observed in this study was life-threatening or fatal bleeding, primarily from the lungs. This occurred infrequently, but was more common in the patient group that received bevacizumab in combination with chemotherapy than in the patient group that received only chemotherapy. A full description of side effects observed in this trial will be presented at the ASCO Annual Meeting in May, as well.
Bevacizumab, a humanized monoclonal antibody, is designed to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogenesis, the formation of new blood vessels to the tumor.
"This trial represents another step in a series of recent important advances in treatment for patients with advanced lung cancer," said James H. Doroshow, M.D., director of NCI's Division of Cancer Treatment and Diagnosis and leader of NCI's Clinical Trials Working Group. "Important progress continues to be made by targeting molecular pathways critical to the growth and survival of cancer cells. It is through better understanding of these molecular processes that significant advances will be made in the treatment of this disease."