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Lung cancer blog: Targretin may prolong survival in subgroup of patients with lung cancer

Lung cancer blog Lung cancer main Non small cell  

Aug 31, 2005

Targretin may prolong survival in subgroup of patients with lung cancer

Targretin may prolong survival in subgroup of patients with lung cancerTargretin® is a member of a subclass of retinoids that selectively activates retinoid X receptors. This drug is FDA approved for the treatment of lymphoma that affects the skin.

New research indicates that Targretin may be may be an effective drug in the fight against non-small cell lung cancer. In the recent meeting of the American Society of Oncology (ASCO), R. Govindan of Washington University Medical Center in St. Louis presented data showing the effectiveness of Targretin in the treatment of non-small cell lung cancer.

Results of the phase II trial of single-agent Targretin in patients with advanced non-small cell lung cancer, who had failed on previous chemotherapies, were treated with single agent targretin. This is the first study to evaluate the benefit of targretin as a single agent in the treatment of patients with non-small cell lung cancer.

At the time of presentation data from 146 were available and this showed a median survival of five months and overall one-year survival was 15 percent in previously treated patients with non-small cell lung cancer. The data was also analyzed to evaluate the survival of patients based on the triglyceride response to Targretin treatment. This was done because recently it was shown that high-grade triglycerided levels after treatment with targretin has been correlated with improved survival in patients with non-small cell lung cancer. With this sub analysis, two populations of patients were identified. Those with high triglyceridemia (grade 1 - 4) had a median survival of seven months and a projected one-year survival of 23%, compared with those with no hypertriglyceridemia who had a median survival of two months and a projected one-year survival of only 5%.

An inch forward in the treatment of lung cancer is good news, and this is especially true when the new advance may potentially improved survival in this sinister disease.

Scott      Return to Lung Cancer Blog Main


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Lung cancer blog: Targretin may prolong survival in subgroup of patients with lung cancer

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