MedicineWorld.Org
Your gateway to the world of medicine
Home
News
Cancer News
About Us
Cancer
Health Professionals
Patients and public
Contact Us
Disclaimer

Lung Cancer Blog: Hormonal Therapy For Lung Cancer?

Return to Lung Cancer Blog Main Cancer Blog List Of Blogs  

Dec 15, 2005

Hormonal Therapy For Lung Cancer?

Hormonal Therapy For Lung Cancer?
(Image courtesy of University of Alabama at Birmingham). It is already known that, much like breast tumors, some lung tumors require estrogen to grow. Now a medical student conducting research on a Howard Hughes Medical Institute and colleagues have managed to stop the growth of human lung cancer cells in mice with a class of breast cancer drugs called aromatase inhibitors. Her findings are reported in recent issue of the journal Cancer Research.

"It was a natural progression of the work that had already been done linking estrogen and lung cancer," said Olga Weinberg, who delayed her fourth year at Vanderbilt University School of Medicine to work on the project.

"We followed one of the clues as to why this is happening, namely that estrogen drives the growth of certain types of lung cancer in women." said senior author Richard Pietras, Weinberg's research mentor at the University of California at Los Angeles.

"The production of estrogen takes several steps, and aromatase is the key to the process," said Weinberg. "Without aromatase, you don't get estrogen."

To confirm that lung cancer needs aromatase, the team first searched for the enzyme in laboratory-grown lung cancer cells. After finding it there, they also searched 53 non-small cell lung tumor samples from patients Using an antibody specific for aromatase and immunohistochemistry techniques, they found that 88 percent of the specimens from women and 86 percent from men contained high levels of the enzyme.


"Once we saw that aromatase was active, we wanted to see if we could inhibit it with the same drugs they use for breast cancer," said Weinberg. The team treated their cells with the drug anastrozole for 48 hours, finding that it did in fact shut down aromatase activity and retard tumor growth in the lab.

"We found that tumors with both high and low levels of aromatase were sensitive to the drug," said Pietras.

Finally, the team grafted human lung tumors onto mice. One group of mice received anastrozole for 21 days, while a second group did not. The tumors in the mice taking the drug grew 90 percent slower than the tumors in the untreated mice.

Scott      


Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Janet      


Lung cancer
We engage a never-ending daily struggle to understand and defeat the hidden mysteries of cancer. This is a long and laborious fight, but some moments stand out as grim reminders of the severity of the problem and ruthlessness of the enemy. We recently heard about the sad demise of Peter Jennings, who was the news anchor of ABC News for a long time.

Lung Cancer Blog: Hormonal Therapy For Lung Cancer?

Cancer blog| Colon cancer blog| Prostate cancer blog| Prostate cancer news| Comprehensive information on lung cancer| General information on lung cancer| Lung cancer information| Lung cancer blog| Non-small cell lung cancer| Small cell lung cancer| Chemotherapy of small cell lung cancer| Newer drugs in the treatment of small cell lung cancer| Prophylactic cranial irradiation| Treatment of extensive stage small cell lung cancer| Treatment of limited stage small cell lung cancer| Treatment of small cell lung cancer surgery| Epidemiology of lung cancer| Introduction to lung cancer| Prognostic factors in lung cancer| Risk factors for lung cancer| Screening and prevention of lung cancer| Signs and symptoms due to distant spread of lung cancer| Signs and symptoms of lung cancer| Staging of lung cancer|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.