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Lung Cancer Blog: New Clues To Iressa And Tarceva Resistance

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Feb 23, 2006

New Clues To Iressa And Tarceva Resistance

New Clues To Iressa And Tarceva Resistance
Thanks to research, now there is more information regarding the mechanism of resistance of cancer cells to drugs like Tarceva (erlotinib) and Iressa (gefitinib).

These drugs belonging to the group of EGFR receptor blockers stop the growth of certain cancers by targeting signaling molecules that are essential to the survival of cancer cells. Researchers have recently found that those who harbor a mutation in the EGFR gene may actually benefit patients in terms of response to treatment. These drugs are however effective only in 10 percent of patients with non-small cell lung cancer, for which subtype of lung cancer this drug is indicated. Also patients who receive this drug may develop acquired resistance during the course of the treatment.

To investigate the issue of drug-resistance, researchers followed six NSCLC patients who'd been treated with either Tarceva or Iressa and later developed secondary resistance. They analyzed tumor samples taken from the patients at various points before and during treatment.

The researchers found that in three of the six patients, tumors continued to grow despite continued therapy. These tumors were found to contain a second mutation in the EGFR gene. Further research revealed this second mutation conferred drug resistance to the EGFR mutant genes that would otherwise be sensitive to Tarceva and Iressa.

The study appears in the Feb. 22 issue of PLoS Medicine.


Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer. publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.


Lung cancer
We engage a never-ending daily struggle to understand and defeat the hidden mysteries of cancer. This is a long and laborious fight, but some moments stand out as grim reminders of the severity of the problem and ruthlessness of the enemy. We recently heard about the sad demise of Peter Jennings, who was the news anchor of ABC News for a long time.

Lung Cancer Blog: New Clues To Iressa And Tarceva Resistance

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