Your gateway to the world of medicine
Cancer News
About Us
Health Professionals
Patients and public
Contact Us

Lung cancer blog: Key Protien In Lung Cancer Development Identified

Back to Lung cancer blog Lung cancer main Non small cell  

Nov 8, 2005

Key Protien In Lung Cancer Development Identified

Key Protien In Lung Cancer Development Identified
Picture of TGF-B-receptor courtesy of Mayo clinic
A single protein may be all that may take for a normal healthy lung to develop into lung cancer as per the latest research form Vanderbilt University in Nashville. Researchers at Vanderbilt University found that type 2 receptors for Transforming Growth Factor-b (TGF-b), which is a family of proteins that controls key functions such as cell growth and death, were missing in non-small cell lung cancer victims. Further studies were carried out in mouse with injection of lung cancer cells and this showed that only smaller and less aggressive tumors were developing in those mice carrying the type 2 TGF-b receptors.

"We've established for the first time that these important molecules are either missing or that their action is reduced in three-quarters of all cases of lung cancer," said lead researcher Professor Pran Datta. "When we restored the molecules in lung cancer cells in mice, they reduced the ability of the cells to grow as tumors," he wrote in the British Journal of Cancer.

Now that link between type 2 TGF-b receptors and lung cancer the task would be to find out how or why the key receptor molecules go missing as the disease develops, in order to find a way of treating it..

Most mammalian cells express three abundant high affinity receptors which can bind and be cross-linked to TGF-b: the type 1), type 2 , and the type 3 receptors. While TGF-b1 binds with high affinity to the type I, II and III receptors at the cell surface, TGF-b2 binds with high affinity only to the type III receptor while binding poorly to the majority of the type I and type II receptors.

Scott      Return to Lung Cancer Blog Main

Do You Read All Of Our Cancer Blogs?

Do You Read All Of Blogs?
Do you read all of the blogs published by Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer. publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Heart watch blog: About 13 million Americans suffer from coronary artery disease. Coronary artery disease is the leading cause of death in American men and women amounting a staggering 20 percent of all causes of death. The tremendous responsibility of running a heart blog is entrusted to Daniel. He is creating blog posts with the help and support of other bloggers.


Lung cancer
We engage a never-ending daily struggle to understand and defeat the hidden mysteries of cancer. This is a long and laborious fight, but some moments stand out as grim reminders of the severity of the problem and ruthlessness of the enemy.

Lung cancer blog: Key Protien In Lung Cancer Development Identified

Cancer blog| Colon cancer blog| Prostate cancer blog| Comprehensive information on lung cancer| General information on lung cancer| Lung cancer information| Lung cancer blog| Non-small cell lung cancer| Small cell lung cancer| Chemotherapy of small cell lung cancer| Newer drugs in the treatment of small cell lung cancer| Prophylactic cranial irradiation| Treatment of extensive stage small cell lung cancer| Treatment of limited stage small cell lung cancer| Treatment of small cell lung cancer surgery| Epidemiology of lung cancer| Introduction to lung cancer| Prognostic factors in lung cancer| Risk factors for lung cancer| Screening and prevention of lung cancer| Signs and symptoms due to distant spread of lung cancer| Signs and symptoms of lung cancer| Staging of lung cancer|

Copyright statement
The contents of this web page are protected. Legal action may follow for reproduction of materials without permission.