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Lung cancer blog: Adding Efaproxiral To Radiation May Improves Survival in NSCLC

Back to Lung cancer blog Lung cancer main Non small cell  

Oct 21, 2005

Adding Efaproxiral To Radiation May Improves Survival in NSCLC

Adding Efaproxiral To Radiation May Improves Survival in NSCLC
Adding efaproxiral (Efaproxyn, RSR13) to radiation therapy after chemotherapy may improve outcome in patients with non-small cell lung cancer, which is irremovable by surgery as per a new study. This improvement in survival comes without increasing the toxicities with the addition of efaproxiral.

The study enrolled 51 patients to receive treatment with paclitaxel and carboplatin followed by radiation therapy with concurrent efaproxiral.

After two months of follow up, the disease progressed in two patients and remained stable in three patients. Seven patients were not evaluated for various reasons. Three patients achieved complete disappearance of the tumor and 34 patients achieved reduction of tumor size to at least 50 percent of the original size. This would amount to an overall response rate of 75 percent.

The researchers compared the survival of these patients to survival in RTOG-94-10, which enrolled patients with similar chrematistics and found that the median survival of 20.6 months observed in the current study was longer than 17.9 months as reported in RTOG-94-10.

The results of this trial should be interpreted with caution since this is small phase II study and selection bias may have influenced the treatment outcome. Results need to be confirmed in a larger randomized clinical trial.

Scott      Return to Lung Cancer Blog Main


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Lung cancer
We engage a never-ending daily struggle to understand and defeat the hidden mysteries of cancer. This is a long and laborious fight, but some moments stand out as grim reminders of the severity of the problem and ruthlessness of the enemy.

Lung cancer blog: Adding Efaproxiral To Radiation May Improves Survival in NSCLC

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