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Lung cancer blog: Cancer Vaccine Shows Promising Safety and Efficacy

Back to Lung cancer blog Lung cancer main Non small cell  

Sep 12, 2005

Lung Cancer Vaccine Shows Promising Safety and Efficacy

Cancer Vaccine Shows Promising Safety and EfficacyA few days ago, I wrote how I would like to see a vaccine for lung cancer, where you could vaccinate a smoker to prevent the occurrence of lung cancer, just like how you vaccinate a child against chicken pox.

Introgen Therapeutics, Inc. has a lung cancer vaccine in phase II clinical trials named as INGN 225. This is not a vaccine to prevent the occurrence of lung cancer in smokers, but is a treatment for patients who have been diagnosed with small cell lung cancer.

Interim results from an ongoing phase II clinical trial with this vaccine were recently presented at the 13th International Conference on Gene Therapy of Cancer. It showed that this vaccine is well tolerated and appears to sensitize lung tumors to additional chemotherapy, with 62 percent of patients who received second-line chemotherapy exhibiting objective responses. There were no appreciable INGN 225 related toxicities in any of the treated patients

INGN 225 is a personalized vaccine consisting of a cancer patient's dendritic cells, that utilizes the p53 tumor suppressor gene, to stimulate a cancer patient's immune system to destroy cancer cells.

"Historically, the expected objective response rate in patients with this type of advanced lung cancer is less than 25 percent," said Dmitry Gabrilovich, M.D., Ph.D., professor of oncology at the H. Lee Moffitt Cancer Center and co-principal investigator of the study. "The results of post- vaccination second-line chemotherapy are striking -- double what we would predict in this patient population. These data strongly suggest that INGN 225 sensitizes lung cancer cells to the effects of chemotherapy and may in fact significantly enhance the efficacy of subsequent chemotherapy."

All I have to say is every small step forward is an important step forward in the treatment of lung cancer.

Scott      Return to Lung Cancer Blog Main


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Lung cancer blog: Cancer Vaccine Shows Promising Safety and Efficacy

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